Results 151 to 160 of about 96,813 (217)

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Factors Affecting Recollapse of the Augmented Vertebrae After Percutaneous Vertebral Augmentation: A Prospective Study

AGING MEDICINE, EarlyView.
To investigate the relevant factors of augmented vertebrae recollapse after percutaneous vertebral augmentation (PVA) for the treatment of osteoporotic vertebral compression fractures (OVCFs). Intervertebral cleft (IVC) and those with PVP intervention are at higher risk of recollapse.
Yawen Zhang, Junchuan Liu, Maoyu Zhao, Yudian Qiu, Quan Ji, Nan Min, Qiang Wang   +6 more
wiley   +1 more source

The Impact of Early Postoperative Blood Pressure Variability and Hypertension Status on 90‐Day Functional Outcomes in Acute Ischemic Stroke due to Large Vessel Occlusion Patients Treated With Mechanical Thrombectomy

AGING MEDICINE, EarlyView.
Early postoperative blood pressure variability independently predicts poor 90‐day functional outcomes in AIS‐LVO patients after mechanical thrombectomy, with the adverse effect amplified in those with pre‐existing hypertension. Maintaining stable blood pressure in the early postoperative period may improve recovery in this high‐risk population ABSTRACT
Yunpeng Liu, Yiqi Liu, Zeping Jin, Jumei Huang, Yang Wang   +4 more
wiley   +1 more source

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Neurological complications in AIDS

Journal of Neurology, 1987
Neurological complications in the acquired immunodeficiency syndrome (AIDS) are an important aspect of this new infectious disease and occur frequently. The existence of neurotropic variants of the human immunodeficiency virus (HIV), the causative agent of AIDS, is probable.
P A, Fischer, W, Enzensberger
openaire   +2 more sources

NEUROLOGICAL COMPLICATIONS IN HEMOPHILIA

Acta Paediatrica, 1981
ABSTRACT. Lütschg, J. and Vassella, F. (Department of Child Neurology, University Children's Hospital, Berne, Switzerland) Neurological Complications in Hemophilia. Acta Paediatr Scand, 70:235, 1981. –The clinical data of 59 patients with hemophilia A or B are reviewed.
J, Lütschg, F, Vassella
openaire   +2 more sources