Results 31 to 40 of about 54,758 (258)

Spontaneous subdural effusion in a hospitalized Covid-19 patient: Case report

Brain Hemorrhages, 2023
Subdural effusions (SE) have already been associated with several viruses, but there are few associations with Covid-19 reported to date, and all of them had one thing in common: the presence of superimposed bacterial rhinosinusitis. Here we describe the
Artur Eduardo Martio, Ana Luisa dos Santos Carregosa, Octávio Ruschel Karam, Wagner Lazaretto Padua, Paulo Moacir Mesquita Filho   +4 more
doaj   +1 more source

The influence of intrathecal injection of methotrexate and dexamethasone on neuropsychiatric systemic lupus erythematosus (NPSLE): a retrospective cohort study of 386 patients with NPSLE

Arthritis Research & Therapy, 2023
Background Neuropsychiatric involvement is one of the major concerns in systemic lupus erythematosus (SLE). The therapeutic effect of intrathecal treatment of methotrexate and dexamethasone has been investigated in some exploratory studies, but its ...
Yuxue Nie, Boyuan Sun, Xin He, Minmin Zheng, Di Wu, Yunjiao Yang, Li Zhang, Wei Bai, Nan Jiang, Lin Qiao, Can Huang, Shuang Zhou, Jiaxin Zhou, Linyi Peng, Jingwen Niu, Mengtao Li, Yan Zhao, Xiaofeng Zeng, Li Wang, Wen Zhang   +19 more
doaj   +1 more source

Leptospirosis presenting as ascending progressive leg weakness and complicating with acute pancreatitis

Brazilian Journal of Infectious Diseases
Leptospirosis is a spirochetal bacterial infection of great public health importance. It has a broad spectrum of clinical manifestations which goes from subclinical infection and self-limited anicteric febrile illness (80-90% of all cases) to icteric ...
Andre Pacheco Silva, Luciana Bonnassis Burg, João Felipe Schadeck Locatelli, Joice Manes, Morgana Crispim   +4 more
doaj   +1 more source

Common Neurologic Features of Lyme Disease That May Present to a Rheumatologist

Pathogens, 2023
Lyme disease, caused by Borrelia burgdorferi (Bb) infection, has a broad spectrum of clinical manifestations and severity. Patients with possible Lyme disease may seek out or be referred to rheumatologists.
Swati Govil, Eugenio Capitle, Alexandra Lacqua, Reena Khianey, P.K. Coyle, Steven E. Schutzer   +5 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Neurologic manifestations of AIDS: a review of fifty cases in Santos

São Paulo Medical Journal
OBJECTIVE: To review the neurologic manifestations of AIDS in patients who were admitted to Hospital Guilherme Álvaro (HGA) due to any clinical manifestation of the disease. DESIGN: Case series.
Yára Dadalti Fragoso, Vanessa Mendes, Ana Paula Margonari Adamo, Bosco Luciana Paschoareli, Carlos Augusto Fernandes Tavares   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Catastrophic neurologic manifestations of a common immunodeficiency syndrome

Journal of Pediatric Critical Care, 2015
A high index of suspicion is needed in pediatric patients with neurological symptoms being the sole presenting manifestation, to diagnose infection with the Human Immunodeficiency Vnus (HIV).
Nitika Agrawal, Gnanam Ram, Shiv Kumar, Bidisha Banarjee   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source