Results 1 to 10 of about 659,580 (288)

Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse

Alzheimer’s Research & Therapy, 2023
Background Toll-like receptor 3 (TLR3) plays an important role in the immune/inflammatory response in the nervous system and is a main pathological feature of Alzheimer’s disease (AD).
Shang Wang, Taiyang Zhu, Wanyan Ni, Chao Zhou, Hui Zhou, Li Lin, Yuting Hu, Xiaoyu Sun, Jingjing Han, Yan Zhou, Guoliang Jin, Jie Zu, Hongjuan Shi, Xingxing Yang, Zuohui Zhang, Fang Hua   +15 more
doaj   +1 more source

Evaluation of Brain SPECT with 99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism

Parkinson's Disease, 2022
Introduction. Brain SPECT with 99mTc-TRODAT-1 (SPECT-TRODAT) may be a useful tool in the differential diagnosis of Parkinsonism. Objective. To compare results of SPECT-TRODAT with clinical findings in patients with Parkinsonism. Methods. We evaluated 153
Giorgio Fabiani, Carlos Henrique Ferreira Camargo, Raul Martins Filho, Gabriel Sampaio Froehner, Hélio Afonso Ghizoni Teive   +4 more
doaj   +1 more source

Serum Level of Brain-Derived Neurotrophic Factor and Thrombotic Type Are Predictive of Cognitive Impairment in the Acute Period of Ischemic Strokes Patients

Neurology Research International, 2023
40–70% of patients after a stroke, including a mild one, may experience cognitive impairment. Brain-derived neurotrophic factor (BDNF) plays a significant role in the pathogenesis and rehabilitation of ischemic stroke and also affects the patients ...
Yaroslava Yu. Havlovska, Nataliya V. Lytvynenko, Anastasiia D. Shkodina   +2 more
doaj   +1 more source

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge, Thomas J. Tamsett, Christopher M. Treleaven, Tatyana V. Taksir, Peter Piepenhagen, S. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin   +7 more
doaj   +1 more source

Astroglia In Neurological Diseases [PDF]

Future Neurology, 2013
Astroglia encompass a subset of versatile glial cells that fulfill a major homeostatic role in the mammalian brain. Since any brain disease results from failure in brain homeostasis, astroglial cells are involved in many, if not all, aspects of neurological and/or psychiatric disorders.
Verkhratsky, Alexei, Rodríguez, José J., Parpura, Vladimir   +2 more
openaire   +3 more sources

Neurological diseases [PDF]

Clinical Chemistry and Laboratory Medicine (CCLM), 2021
T.M. Craft, P.M. Upton
  +6 more sources

Pseudo Chiari with holocord syringomyelia secondary to cerebrospinal fluid hypotension. Case report

Interdisciplinary Neurosurgery, 2022
Introduction: Pseudo-Chiari malformation results from caudal displacement of brain structures secondary to cerebrospinal fluid (CSF) hypotension. Some case reports in the syringomyelia literature are associated with a pseudo-Chiari malformation.
Emiliano Lorefice, Sebastián J.M Giovannini, Andrés Cervio, Santiago Condomí Alcorta, Rubén Mormandi   +4 more
doaj   +1 more source

Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis

Scientific Reports, 2021
Aberrant cholesterol homeostasis is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disease that is due to motor neuron (MN) death. Cellular toxicity from excess cholesterol is averted when it is enzymatically
James C. Dodge, Jinlong Yu, S. Pablo Sardi, Lamya S. Shihabuddin   +3 more
doaj   +1 more source

Functional connectivity of the language area in migraine: a preliminary classification model

BMC Neurology, 2023
Background Migraine is a complex disorder characterized by debilitating headaches. Despite its prevalence, its pathophysiology remains unknown, with subsequent gaps in diagnosis and treatment.
Chen Gou, Shuangfeng Yang, Qianmei Hou, Peter Rudder, Onur Tanglay, Isabella Young, Tingting Peng, Weiwei He, Liuyi Yang, Karol Osipowicz, Stephane Doyen, Negar Mansouri, Michael E. Sughrue, Xiaoming Wang   +13 more
doaj   +1 more source

Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic stroke

Signal Transduction and Targeted Therapy, 2023
Acute ischemic stroke (AIS) is a major cause of disability and mortality worldwide. Non-cardioembolic ischemic stroke (NCIS), which constitutes the majority of AIS cases, is highly heterogeneous, thus requiring precision medicine treatments.
Lingling Ding, Yu Liu, Xia Meng, Yong Jiang, Jinxi Lin, Si Cheng, Zhe Xu, Xingquan Zhao, Hao Li, Yongjun Wang, Zixiao Li   +10 more
doaj   +1 more source