Results 11 to 20 of about 1,042,114 (299)

Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis

Scientific Reports, 2021
Aberrant cholesterol homeostasis is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disease that is due to motor neuron (MN) death. Cellular toxicity from excess cholesterol is averted when it is enzymatically
James C. Dodge, Jinlong Yu, S. Pablo Sardi, Lamya S. Shihabuddin   +3 more
doaj   +1 more source

COVID-19 pandemic and individuals with severe mental illness: A comparative study of community mental health centers' early experiences in COVID-19 pandemic (tur)

Klinik Psikiyatri Dergisi, 2022
INTRODUCTION: In this study, we aimed to determine the effects of the early phase of the COVID-19 pandemic on the services in Community Mental Health Centers (CMHCs) and on the patients followed up by the CMHC. In this direction, the clinical data of the
Nazife Gamze Usta Sağlam, Engin Emrem Beştepe, Filiz İzci, İpek Sarıkaya, Haluk Usta, Fatih Baz   +5 more
doaj   +1 more source

Functional connectivity of the language area in migraine: a preliminary classification model

BMC Neurology, 2023
Background Migraine is a complex disorder characterized by debilitating headaches. Despite its prevalence, its pathophysiology remains unknown, with subsequent gaps in diagnosis and treatment.
Chen Gou, Shuangfeng Yang, Qianmei Hou, Peter Rudder, Onur Tanglay, Isabella Young, Tingting Peng, Weiwei He, Liuyi Yang, Karol Osipowicz, Stephane Doyen, Negar Mansouri, Michael E. Sughrue, Xiaoming Wang   +13 more
doaj   +1 more source

Neurologic Wilson's disease [PDF]

Annals of the New York Academy of Sciences, 2010
Despite a long history, Wilson's disease, an autosomal recessive disease caused by mutations in the ATP7B gene, remains a commonly misdiagnosed import disease. Mutations in ATP7B result in abnormal copper metabolism and subsequent toxic accumulation of copper.
openaire   +3 more sources

Epigenetics and triplet-repeat neurological diseases [PDF]

, 2015
The term ‘junk DNA’ has been reconsidered following the delineation of the functional significance of repetitive DNA regions. Typically associated with centromeres and telomeres, DNA repeats are found in nearly all organisms throughout their genomes ...
Festenstein, RJ, Nageshwaran, S
core   +2 more sources

Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response [PDF]

, 2012
Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage.
A Hainard, B Beutler, B Courtioux, B Namangala, CA Hunter, CA Hunter, CF Calvo, EN Benveniste, F Checchi, F Esamai, G Binz, H Reiber, H Reiber, H Reiber, Hansotto Reiber, HY Hassan, J Kabore, J Rodgers, Jeremy M. Sternberg, JM Sternberg, JM Sternberg, JM Sternberg, Joseph Mathu Ndung'u, KW Moore, L Maclean, L MacLean, L MacLean, L MacLean, LJ Morrison, LM MacLean, Lorna MacLean, M Sjogren, MC Okomo-Assoumou, P Cattand, PD Eckersall, Peter G. E. Kennedy, PG Kennedy, PGE Kennedy, PGE Kennedy, TN Baral, V Jamonneau, V Lejon, V Lejon, V Lejon, W Masocha   +44 more
core   +9 more sources

Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic stroke

Signal Transduction and Targeted Therapy, 2023
Acute ischemic stroke (AIS) is a major cause of disability and mortality worldwide. Non-cardioembolic ischemic stroke (NCIS), which constitutes the majority of AIS cases, is highly heterogeneous, thus requiring precision medicine treatments.
Lingling Ding, Yu Liu, Xia Meng, Yong Jiang, Jinxi Lin, Si Cheng, Zhe Xu, Xingquan Zhao, Hao Li, Yongjun Wang, Zixiao Li   +10 more
doaj   +1 more source

Response to Telemedicine Visits From Patients With Parkinsonism During the COVID-19 Pandemic on Postvisit Surveys

Journal of Patient Experience, 2021
Parkinson’s disease and parkinsonism are common chronic neurodegenerative disorders that tend to affect older adults and cause physical and sometimes cognitive limitations.
Wissam Deeb MD, Christopher W Hess MD, Noheli Gamez MHA, Bhavana Patel DO, Kathryn Moore MD, Melissa J Armstrong MD, MSc   +5 more
doaj   +1 more source

A Prospective Study Comparing Subperiosteal Versus Subdural Drain After Burr-hole Drainage of Chronic Subdural Hematoma

National Board of Examinations Journal of Medical Sciences, 2023
Aims: The aim of our study was to perform a comparison between the efficacy of subperiosteal drain and subdural drain, and to evaluate any differences in terms of functional outcome in the treatment of symptomatic CSDH.
Mohammad Sarwar, Laxminarayan Tripathy, Harsh Jain, Sunandan Basu   +3 more
doaj   +1 more source

Genetic neurological channelopathies: molecular genetics and clinical phenotypes [PDF]

, 2015
Evidence accumulated over recent years has shown that genetic neurological channelopathies can cause many different neurological diseases. Presentations relating to the brain, spinal cord, peripheral nerve or muscle mean that channelopathies can impact ...
Hanna, MG, Kullmann, DM, Spillane, J
core   +1 more source