Results 1 to 10 of about 717,165 (311)

Cathepsins in Neurological Diseases. [PDF]

Int J Mol Sci
Cathepsins, a family of lysosomal proteases, play critical roles in maintaining cellular homeostasis through protein degradation and modulation of immune responses. In the central nervous system (CNS), their functions extend beyond classical proteolysis, influencing neuroinflammation, synaptic remodeling, and neurodegeneration.
Lewandowski D, Konieczny M, Różycka A, Chrzanowski K, Owecki W, Kalinowski J, Stepura M, Jagodziński P, Dorszewska J.   +8 more
europepmc   +3 more sources

Insomnia in neurological diseases [PDF]

Neurological Research and Practice, 2021
Insomnia is defined as difficulties of initiating and maintaining sleep, early awakening and poor subjective sleep quality despite adequate opportunity and circumstances for sleep with impairment of daytime performance.
Geert Mayer, Svenja Happe, Stefan Evers, Wiebke Hermann, Sabine Jansen, Ulf Kallweit, Maria-Lucia Muntean, Dieter Pöhlau, Dieter Riemann, Michael Saletu, Melanie Schichl, Wolfgang J. Schmitt, Friederike Sixel-Döring, Peter Young   +13 more
doaj   +5 more sources

Vitamin D in Neurological Diseases [PDF]

, 2022
Vitamin D may have multiple effects on the nervous system and its deficiency can represent a possible risk factor for the development of many neurological diseases.
Nicola De Stefano, Serenella Servidei, Domenico Plantone, Guido Primiano, Carlo Manco, Sara Locci   +5 more
core   +4 more sources

Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse

Alzheimer’s Research & Therapy, 2023
Background Toll-like receptor 3 (TLR3) plays an important role in the immune/inflammatory response in the nervous system and is a main pathological feature of Alzheimer’s disease (AD).
Shang Wang, Taiyang Zhu, Wanyan Ni, Chao Zhou, Hui Zhou, Li Lin, Yuting Hu, Xiaoyu Sun, Jingjing Han, Yan Zhou, Guoliang Jin, Jie Zu, Hongjuan Shi, Xingxing Yang, Zuohui Zhang, Fang Hua   +15 more
doaj   +1 more source

Idebenone: Clinical Potential Beyond Neurological Diseases. [PDF]

Drug Des Devel Ther
Bin Yi,1– 4,* Jun Zeng,1– 4,* Jiashuo Li,1– 4,* Kunfeng Liu,1– 4 Xiaocheng Zhu,4,5 Xiang Chen,4,5 Yang Gao1– 4 1Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ...
Yi B, Zeng J, Li J, Liu K, Zhu X, Chen X, Gao Y.   +6 more
europepmc   +2 more sources

Evaluation of Brain SPECT with 99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism

Parkinson's Disease, 2022
Introduction. Brain SPECT with 99mTc-TRODAT-1 (SPECT-TRODAT) may be a useful tool in the differential diagnosis of Parkinsonism. Objective. To compare results of SPECT-TRODAT with clinical findings in patients with Parkinsonism. Methods. We evaluated 153
Giorgio Fabiani, Carlos Henrique Ferreira Camargo, Raul Martins Filho, Gabriel Sampaio Froehner, Hélio Afonso Ghizoni Teive   +4 more
doaj   +1 more source

Serum Level of Brain-Derived Neurotrophic Factor and Thrombotic Type Are Predictive of Cognitive Impairment in the Acute Period of Ischemic Strokes Patients

Neurology Research International, 2023
40–70% of patients after a stroke, including a mild one, may experience cognitive impairment. Brain-derived neurotrophic factor (BDNF) plays a significant role in the pathogenesis and rehabilitation of ischemic stroke and also affects the patients ...
Yaroslava Yu. Havlovska, Nataliya V. Lytvynenko, Anastasiia D. Shkodina   +2 more
doaj   +1 more source

Astroglia In Neurological Diseases [PDF]

Future Neurology, 2013
Astroglia encompass a subset of versatile glial cells that fulfill a major homeostatic role in the mammalian brain. Since any brain disease results from failure in brain homeostasis, astroglial cells are involved in many, if not all, aspects of neurological and/or psychiatric disorders.
Verkhratsky, Alexei; id_orcid 0000-0003-2592-9898, Rodríguez, José J., Parpura, Vladimir   +2 more
openaire   +3 more sources

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge, Thomas J. Tamsett, Christopher M. Treleaven, Tatyana V. Taksir, Peter Piepenhagen, S. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin   +7 more
doaj   +1 more source

The immunogenetics of neurological disease [PDF]

Immunology, 2017
SummaryGenes encoding antigen‐presenting molecules within the human major histocompatibility complex (MHC) account for the highest component of genetic risk for many neurological diseases, such as multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis ...
Maneesh K. Misra, Vincent Damotte, Jill A. Hollenbach   +2 more
openaire   +2 more sources