Results 1 to 10 of about 64,270 (263)

Insomnia in neurological diseases [PDF]

Neurological Research and Practice, 2021
Insomnia is defined as difficulties of initiating and maintaining sleep, early awakening and poor subjective sleep quality despite adequate opportunity and circumstances for sleep with impairment of daytime performance.
Geert Mayer, Svenja Happe, Stefan Evers, Wiebke Hermann, Sabine Jansen, Ulf Kallweit, Maria-Lucia Muntean, Dieter Pöhlau, Dieter Riemann, Michael Saletu, Melanie Schichl, Wolfgang J. Schmitt, Friederike Sixel-Döring, Peter Young   +13 more
doaj   +5 more sources

Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse

Alzheimer’s Research & Therapy, 2023
Background Toll-like receptor 3 (TLR3) plays an important role in the immune/inflammatory response in the nervous system and is a main pathological feature of Alzheimer’s disease (AD).
Shang Wang, Taiyang Zhu, Wanyan Ni, Chao Zhou, Hui Zhou, Li Lin, Yuting Hu, Xiaoyu Sun, Jingjing Han, Yan Zhou, Guoliang Jin, Jie Zu, Hongjuan Shi, Xingxing Yang, Zuohui Zhang, Fang Hua   +15 more
doaj   +1 more source

Evaluation of Brain SPECT with 99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism

Parkinson's Disease, 2022
Introduction. Brain SPECT with 99mTc-TRODAT-1 (SPECT-TRODAT) may be a useful tool in the differential diagnosis of Parkinsonism. Objective. To compare results of SPECT-TRODAT with clinical findings in patients with Parkinsonism. Methods. We evaluated 153
Giorgio Fabiani, Carlos Henrique Ferreira Camargo, Raul Martins Filho, Gabriel Sampaio Froehner, Hélio Afonso Ghizoni Teive   +4 more
doaj   +1 more source

Serum Level of Brain-Derived Neurotrophic Factor and Thrombotic Type Are Predictive of Cognitive Impairment in the Acute Period of Ischemic Strokes Patients

Neurology Research International, 2023
40–70% of patients after a stroke, including a mild one, may experience cognitive impairment. Brain-derived neurotrophic factor (BDNF) plays a significant role in the pathogenesis and rehabilitation of ischemic stroke and also affects the patients ...
Yaroslava Yu. Havlovska, Nataliya V. Lytvynenko, Anastasiia D. Shkodina   +2 more
doaj   +1 more source

Astroglia In Neurological Diseases [PDF]

Future Neurology, 2013
Astroglia encompass a subset of versatile glial cells that fulfill a major homeostatic role in the mammalian brain. Since any brain disease results from failure in brain homeostasis, astroglial cells are involved in many, if not all, aspects of neurological and/or psychiatric disorders.
Verkhratsky, Alexei; id_orcid 0000-0003-2592-9898, Rodríguez, José J., Parpura, Vladimir   +2 more
openaire   +3 more sources

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease

Alzheimer’s Research & Therapy, 2022
Background Gangliosides are highly enriched in the brain and are critical for its normal development and function. However, in some rare neurometabolic diseases, a deficiency in lysosomal ganglioside hydrolysis is pathogenic and leads to early-onset ...
James C. Dodge, Thomas J. Tamsett, Christopher M. Treleaven, Tatyana V. Taksir, Peter Piepenhagen, S. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin   +7 more
doaj   +1 more source

The immunogenetics of neurological disease [PDF]

Immunology, 2017
SummaryGenes encoding antigen‐presenting molecules within the human major histocompatibility complex (MHC) account for the highest component of genetic risk for many neurological diseases, such as multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis ...
Maneesh K. Misra, Vincent Damotte, Jill A. Hollenbach   +2 more
openaire   +2 more sources

Pseudo Chiari with holocord syringomyelia secondary to cerebrospinal fluid hypotension. Case report

Interdisciplinary Neurosurgery, 2022
Introduction: Pseudo-Chiari malformation results from caudal displacement of brain structures secondary to cerebrospinal fluid (CSF) hypotension. Some case reports in the syringomyelia literature are associated with a pseudo-Chiari malformation.
Emiliano Lorefice, Sebastián J.M Giovannini, Andrés Cervio, Santiago Condomí Alcorta, Rubén Mormandi   +4 more
doaj   +1 more source

Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis

Scientific Reports, 2021
Aberrant cholesterol homeostasis is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disease that is due to motor neuron (MN) death. Cellular toxicity from excess cholesterol is averted when it is enzymatically
James C. Dodge, Jinlong Yu, S. Pablo Sardi, Lamya S. Shihabuddin   +3 more
doaj   +1 more source

COVID-19 pandemic and individuals with severe mental illness: A comparative study of community mental health centers' early experiences in COVID-19 pandemic (tur)

Klinik Psikiyatri Dergisi, 2022
INTRODUCTION: In this study, we aimed to determine the effects of the early phase of the COVID-19 pandemic on the services in Community Mental Health Centers (CMHCs) and on the patients followed up by the CMHC. In this direction, the clinical data of the
Nazife Gamze Usta Sağlam, Engin Emrem Beştepe, Filiz İzci, İpek Sarıkaya, Haluk Usta, Fatih Baz   +5 more
doaj   +1 more source