Results 41 to 50 of about 659,580 (288)

The Relationship of Serum Magnesium Levels with Etiology, Lesion Size, and Localization in Ischemic Stroke

Boğaziçi Tıp Dergisi, 2022
INTRODUCTION: Magnesium is known to have important effects on vascular system and deficiency of magnesium triggers vasoconstriction and facilitates vascular endothelial damage.
Mustafa Ülker, Tuğçe Toptan, Rahşan Karacı, Mehmet Demir, Saime Füsun Domaç   +4 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Carotid endarterectomy and blood-brain barrier permeability in subjects with bilateral carotid artery stenosis

Chinese Neurosurgical Journal
Background The increased permeability of the blood–brain barrier (BBB) is related to the occurrence and development of diseases such as acute ischemic stroke, chronic ischemia, or small vessel disease.
Changyu Lu, Chenyu Zhu, Wenjie Li, Huan Zhu, Qihang Zhang, Tong Liu, Tongyu Yang, Yan Zhang   +7 more
doaj   +1 more source

Ruptured Suprasellar Dermoid Cyst presenting with Chemical Meningitis and Blindness

National Board of Examinations Journal of Medical Sciences
Background: Intracranial dermoid cysts (ICDC) are rare benign lesions. They typically originate from the ectoderm and contain dermal elements like hair follicles, sweat glands, sebaceous glands, and sometimes teeth.
Lakshya Varshney, Laxminarayan Tripathy, Harsh Jain, Sunandan Basu, Mohammad Sarwar   +4 more
doaj   +1 more source

The role of NURR1 in metabolic abnormalities of Parkinson’s disease

Molecular Neurodegeneration, 2022
A constant metabolism and energy supply are crucial to all organs, particularly the brain. Age-dependent neurodegenerative diseases, such as Parkinson’s disease (PD), are associated with alterations in cellular metabolism.
Murad Al-Nusaif, Yuting Yang, Song Li, Cheng Cheng, Weidong Le   +4 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Trigeminal neuralgia and posterior fossa meningioma: case report and review of literature

Egyptian Journal of Neurosurgery, 2019
Trigeminal neuralgia may be idiopathic or may involve other causes. It can be secondary to posterior fossa tumors many times. In the present case, posterior fossa meningioma was detected with trigeminal neuralgia together. However, relevant meningioma is
Hasan Burak Gunduz, Yaser Ozgunduz, Abdullah Emre Tacyildiz, Erhan Emel, Murad Asilturk   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells

Neurobiology of Disease, 2015
Heterozygous mutations in GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), are a major risk factor for sporadic Parkinson's disease (PD).
Giulia Ambrosi, Cristina Ghezzi, Roberta Zangaglia, Giovanna Levandis, Claudio Pacchetti, Fabio Blandini   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source