Results 241 to 250 of about 1,882,529 (345)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Neurological Manifestations and High Viral Load as Independent Predictors of Mortality in Severe Fever With Thrombocytopenia Syndrome. [PDF]

Open Forum Infect Dis
Chen R, Xing Y, Wei W, Wang Y, Wang T, Ouyang R, Wu S, Wang F, Hou H.   +8 more
europepmc   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Neurological manifestations of Allgrove syndrome in patients carrying a potentially founder p.Ser263Pro variant in the AAAS gene. [PDF]

Neurogenetics
Juścińska E, Gadzalska K, Jakiel P, Gorządek M, Pietrusiński M, Płoszaj T, Skoczylas S, Starosz K, Borowiec M, Pastorczak A, Zmysłowska A.   +10 more
europepmc   +1 more source

Dual‐Physical‐Field Nanocatalysis: Injectable Hydrogel Enables Piezo‐Photothermal Synergy for Breast Cancer Therapy

Advanced Science, EarlyView.
ABSTRACT Piezocatalytic therapy (PCT) harnesses mechanical energy to generate tumor‐lethal reactive oxygen species (ROS), but its efficacy is limited by rapid electron‐hole recombination and poor intratumoral retention. To overcome these limitations, we engineered heterostructured BiOCl@CuO nanosheets embedded in an injectable, conductive ...
Can Tian, Shihan Xiao, Xuan Chen, Danni Zhang, Zizhen Liu, Jing Wang, Ning Xie, Wei Li   +7 more
wiley   +1 more source

Correction: Neurological manifestations of SARS-CoV-2 infection: protocol for a sub-analysis of the COVID-19 critical care consortium observational study. [PDF]

Front Med (Lausanne)
Battaglini D, Premraj L, Griffee M, Huth S, Fanning J, Whitman G, Bastos Porto D, Arora R, Durham L, Gnall E, Amato M, Williams V, Noel A, De Franca SA, Samoukovic G, Pujo B, Kent D, Marwali E, Al-Fares A, Stecher SS, Panigada M, Giani M, Foti G, Pelosi P, Pesenti A, White NM, Li Bassi G, Suen J, Fraser JF, Robba C, Cho SM.   +30 more
europepmc   +1 more source

Personalized Network‐Guided Neuromodulation Enhances Human Working Memory

Advanced Science, EarlyView.
A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan, Hongming Li, Camille Blaine, Julie Grier, Ethan Hammett, Almaris Figueroa‐Gonzalez, Sarai Garcia, Romain Duprat, Justin Reber, Joseph Deluisi, Christos Davatzikos, Theodore D. Satterthwaite, Yong Fan, Desmond J. Oathes   +13 more
wiley   +1 more source

Neurological Manifestations of Hemolytic Uremic Syndrome: A Comprehensive Review. [PDF]

Brain Sci
Tonkovic U, Bogicevic M, Manzar A, Andrejic N, Sic A, Atanaskovic M, Gajić S, Bontić A, Ksiazek SH, Mijušković A, Stojanović NM, Baralić M.   +11 more
europepmc   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Neurological Manifestations of HEV Infection: A Rare Phenomenon or an Underrecognized Reality? [PDF]

Brain Behav
Iza M, Ramos D, Llauradó A, Restrepo-Vera JL, Pallero M, Granados G, Alemany J, Sotoca J, Sampol J, Martí S, Sanchez-Tejerina D, Salvadó M, Juntas R.   +12 more
europepmc   +1 more source