Results 151 to 160 of about 381,065 (262)

Neurological Manifestations in Adult Survivors of Ebola Virus Disease.

open access: yesJAMA Neurol
Billioux BJ   +19 more
europepmc   +1 more source

BIOCHEMISTRY AND NEUROLOGY: METABOLIC DISORDERS IN DISEASES OF THE CENTRAL NERVOUS SYSTEM

open access: yes
The central nervous system (CNS) is one of the most metabolically active systems in the human body. Proper neuronal function depends on continuous energy production, balanced neurotransmitter metabolism, mitochondrial integrity, and redox homeostasis. Metabolic disturbances can impair neuronal communication, accelerate neurodegeneration, and contribute
Tuychieva Mashhuraxon Alisher qizi   +1 more
openaire   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu   +13 more
wiley   +1 more source

Unmet needs in the care of patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody associated disease: insights from Germany. [PDF]

open access: yesNeurol Res Pract
Giglhuber K   +6 more
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng   +14 more
wiley   +1 more source

Soluble TIM-3 and galectin-9 serve as additional diagnostic biomarkers in primary central nervous system lymphoma. [PDF]

open access: yesJ Neurol
Nishii S   +13 more
europepmc   +1 more source

The central nervous system: some experimental models of neurological diseases [PDF]

open access: yesElectroencephalography and Clinical Neurophysiology, 1970
openaire   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

open access: yesAdvanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu   +8 more
wiley   +1 more source

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