Results 81 to 90 of about 540,580 (353)

A journey through the history of Neurogenetics

Arquivos de Neuro-Psiquiatria, 2021
Since the late 19th century, when several inherited neurological disorders were described, the close relationship between Neurology and heredity were well documented by several authors in a pre-genetic era.
Thiago Yoshinaga Tonholo SILVA, José Luiz PEDROSO, Marcondes Cavalcante FRANÇA JUNIOR, Orlando Graziani Povoas BARSOTTINI   +3 more
doaj   +1 more source

Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy

Journal of Neurology, 2020
Evidences from either small series or spontaneous reporting are accumulating that SARS-CoV-2 involves the Nervous Systems. The aim of this study is to provide an extensive overview on the major neurological complications in a large cohort of COVID-19 ...
N. Rifino, B. Censori, E. Agazzi, D. Alimonti, V. Bonito, Giorgia Camera, M. Conti, C. Foresti, B. Frigeni, S. Gerevini, M. Grimoldi, Sara La Gioia, T. Partziguian, S. Quadri, R. Riva, M. C. Servalli, M. Sgarzi, Benedetta Storti, M. Vedovello, E. Venturelli, M. Vigano’, A. Callegaro, M. Arosio, M. Sessa   +23 more
semanticscholar   +1 more source

Apoptosis in development and disease of the nervous system: II. Apoptosis in childhood neurologic disease

Pediatric Neurology, 1997
The loss of cells in the human nervous system has long been known as the hallmark of incurable degenerative disease. Recent studies that began with attempts to understand cell loss during normal development have now begun to contribute to our understanding of the process of pathological cell loss.
H A, Gelbard, R M, Boustany, N F, Schor
openaire   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Differential expression profiles of lncRNAs and a preliminary study on the mechanism of lncRNA FAM225A in triple seronegative myasthenia gravis

Frontiers in Immunology
BackgroundTriple-seronegative (Triple-SN) myasthenia gravis (MG) is a subtype of MG, and its diagnosis and treatment are challenging. Our study aims to discover new biomarkers and potential therapeutic targets and explore the preliminary mechanisms of ...
Yuehan Hao, Yuehan Hao, Yuehan Hao, Chen Chen, Bo Wang, Bo Wang, Bo Wang, ChunHua Yang, Ying Zhu, Ying Zhu, Ying Zhu, Ruixia Zhu, Ruixia Zhu, Ruixia Zhu   +13 more
doaj   +1 more source

Doxycycline Induces Apoptosis of Brucella Suis S2 Strain-Infected HMC3 Microglial Cells by Activating Calreticulin-Dependent JNK/p53 Signaling Pathway

Frontiers in Cellular and Infection Microbiology, 2021
Neurobrucellosis is a chronic complication of human brucellosis that is caused by the presence of Brucella spp in the central nervous system (CNS) and the inflammation play a key role on the pathogenesis.
Zhao Wang, Yanbai Wang, Huan Yang, Jiayu Guo, Zhenhai Wang, Zhenhai Wang   +5 more
doaj   +1 more source

The Compound Muscle Action Potential as Neurophysiological Marker for Amyotrophic Lateral Sclerosis. [PDF]

, 2016
Objectives: To definite the peripheral nervous involvement in ALS through the repeated use of the compound motor action potential (CMAP) to test the progression of disease, to determine different change of phrenic CMAP and forced vital capacity (FVC) in
CECCANTI , MARCO, FRASCA, VITTORIO, Gori, Maria Cristina, INGHILLERI, Maurizio, ONESTI, EMANUELA, Petrucci, Antonio, Silani, Vincenzo, Tartaglia, Giorgio   +7 more
core  

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source