Results 91 to 100 of about 1,378,158 (305)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky   +8 more
wiley   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim   +3 more
wiley   +1 more source

Cerebral Amyloid Angiopathy-Related Inflammation: Clinical Characteristics and Treatment Experience

open access: yesClinical Interventions in Aging
Xue Wang,1,* Jiaqi Li,1,* Qichang Fu,2,* Honglin Zheng,1,3 Suying Duan,1 Yuan Gao,1,4 Haiyang Luo,1,3 Yuming Xu1,3,4 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou,
Wang X   +7 more
doaj  

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani   +8 more
wiley   +1 more source

Phenotypic Manifestations in Two Cases of Osmotic Demyelination Syndrome

open access: yesInternational Medical Case Reports Journal
Noon Elimam,1 Eman Elimam,2 Victoria Krylova,1 Oleg Lobanov,3 Larysa Panteleienko1,4 1Department of Neurology, Bogomolets National Medical University, Kyiv, Ukraine; 2Department of Neurology, Tbilisi State Medical University, Tbilisi, Georgia ...
Elimam N   +4 more
doaj  

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu   +11 more
wiley   +1 more source

Obacunone Inhibits Microglia-Mediated Neuroinflammation and Ischemic Injury by Targeting Mitogen-Activated Protein Kinase 1

open access: yesJournal of Inflammation Research
Jing Huang,1,2,* Zuobin Hu,1,2,* Jie Zhang,1,2,* Jing Xiao,1,2 Ran Zhang,1,2 Shengnan Xia,2– 5 Haiyan Yang,2– 5 Xinyu Bao,2– 5 Fan Zhang,6 Yun Xu,1– 5 Xiaolei Zhu,1– 5 Jiali Jin1– 5,7 1Department of Neurology, Nanjing Drum Tower ...
Huang J   +11 more
doaj  

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu   +5 more
wiley   +1 more source

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