Results 71 to 80 of about 851,278 (265)

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi   +19 more
wiley   +1 more source

Cerebral Amyloid Angiopathy-Related Inflammation: Clinical Characteristics and Treatment Experience

open access: yesClinical Interventions in Aging
Xue Wang,1,* Jiaqi Li,1,* Qichang Fu,2,* Honglin Zheng,1,3 Suying Duan,1 Yuan Gao,1,4 Haiyang Luo,1,3 Yuming Xu1,3,4 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou,
Wang X   +7 more
doaj  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende   +26 more
wiley   +1 more source

Phenotypic Manifestations in Two Cases of Osmotic Demyelination Syndrome

open access: yesInternational Medical Case Reports Journal
Noon Elimam,1 Eman Elimam,2 Victoria Krylova,1 Oleg Lobanov,3 Larysa Panteleienko1,4 1Department of Neurology, Bogomolets National Medical University, Kyiv, Ukraine; 2Department of Neurology, Tbilisi State Medical University, Tbilisi, Georgia ...
Elimam N   +4 more
doaj  

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick   +19 more
wiley   +1 more source

Obacunone Inhibits Microglia-Mediated Neuroinflammation and Ischemic Injury by Targeting Mitogen-Activated Protein Kinase 1

open access: yesJournal of Inflammation Research
Jing Huang,1,2,* Zuobin Hu,1,2,* Jie Zhang,1,2,* Jing Xiao,1,2 Ran Zhang,1,2 Shengnan Xia,2– 5 Haiyan Yang,2– 5 Xinyu Bao,2– 5 Fan Zhang,6 Yun Xu,1– 5 Xiaolei Zhu,1– 5 Jiali Jin1– 5,7 1Department of Neurology, Nanjing Drum Tower ...
Huang J   +11 more
doaj  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher   +10 more
wiley   +1 more source

ANCA-Associated Vasculitis with Predominant Peripheral and Central Nervous System Involvement: A Case Report

open access: yesJournal of Inflammation Research
Bing Zhang, Chaoyang Jing, Peipei Liu, Jianlei Zhang Department of Neurology, Huaihe Hospital of Henan University, Kaifeng, Henan, 475000, People’s Republic of ChinaCorrespondence: Jianlei Zhang, Department of Neurology, Huaihe Hospital of Henan ...
Zhang B, Jing C, Liu P, Zhang J
doaj  

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett   +8 more
wiley   +1 more source

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