Results 131 to 140 of about 1,143,572 (245)

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis   +4 more
wiley   +1 more source

Neuromuscular block in Italy: a survey of current management.

open access: yes, 2012
BACKGROUND: Little is known about current use of neuromuscular blocking agents by Italian anesthetists. This paper reports the results of a survey conducted to obtain information about current management of neuromuscular block in Italy.
DELLA ROCCA, Giorgio   +5 more
core   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar   +6 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

De Pauliana actione

open access: yes
quam ... pro summis in utroque iure licentiae honoribus & privilegiis consequendis, publicè eruditorum examini subiicit Iacob Block, Hamburgensis, ad diem ... Octobr. ann. 1657, horis locoque consuetisEnthält 50 ThesenDatum hs. erg.: ad diem 3.
Block, Jacob
core   +1 more source

Multifunctional hyaluronic acid hydrogel integrating exosome‐encapsulating gelatin microspheres accelerates skeletal muscle regeneration via TGF‐β1 activation and enhanced myogenic cell viability

open access: yesBMEMat, EarlyView.
Schematic illustration of preparation of injectable H/G@Co@miR‐206 hydrogel for efficient skeletal muscle regeneration in cardiotoxin‐induced skeletal muscle injury SD rat model. Abstract The effective treatment of acute skeletal muscle injuries remains challenging, necessitating therapeutic strategies that concurrently reestablish vascular perfusion ...
Zhengzhe Han   +9 more
wiley   +1 more source

External Acoustic Meatus Approach for Ultrasonographic Evaluation of the Temporomandibular Joint: An Anatomical Validation and Proof‐of‐Concept Study

open access: yesClinical Anatomy, EarlyView.
ABSTRACT Temporomandibular disorders (TMD) represent a public health problem, affecting 31% of adults and the elderly and 11% of children and adolescents. Interest is growing in using ultrasound to evaluate the temporomandibular joint (TMJ). However, researchers need to standardize a reliable method.
Rossella Alberti   +10 more
wiley   +1 more source

Error Traps in Pediatric Neuromuscular Block. [PDF]

open access: yesPaediatr Anaesth
de Sousa GS   +5 more
europepmc   +1 more source

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

open access: yesCytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen   +3 more
wiley   +1 more source

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