Interaction of rocuronium with human liver cytochromes P450
Journal of Pharmacological Sciences, 2015 Rocuronium is a neuromuscular blocking agent acting as a competitive antagonist of acetylcholine. Results of an inhibition of eight individual liver microsomal cytochromes P450 (CYP) are presented. As the patients are routinely premedicated with diazepam,
Milan Adamus +2 more
exaly +3 more sources
Rocuronium for Treatment of Sugammadex Anaphylaxis: A Case Report [PDF]
Case Reports in AnesthesiologyAnaphylaxis presents as a complex and unpredictable intraoperative emergency. Rocuronium is among the most common triggering agents for intraoperative anaphylaxis.
Logan H. Cone +2 more
doaj +2 more sources
Median effective dose of rocuronium for the prevention of succinylcholine-induced fasciculation: an age-stratified study [PDF]
BMC AnesthesiologyBackground Succinylcholine, a commonly used depolarizing neuromuscular blocking relaxant, may produce fasciculation and postoperative myalgia as adverse effects.
Shunping Tian +7 more
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Dilution and slow injection reduces the incidence of rocuronium-induced withdrawal movements in children [PDF]
Korean Journal of Anesthesiology, 2011 BackgroundThe aim of this study was to evaluate whether slow injection of diluted rocuronium could reduce rocuronium-induced withdrawal movements effectively in children.MethodsAfter loss of consciousness, rocuronium 0.6 mg/kg was administered into 171 ...
Young Hee Shin +8 more
doaj +1 more source
Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E Synthesis in Endothelial Cells [PDF]
International Neurourology Journal, 2016 Purpose Rocuronium bromide is a nondepolarizing neuromuscular blocking drug and has been used as an adjunct for relaxation or paralysis of the skeletal muscles, facilitation of endotracheal intubation, and improving surgical conditions during general ...
Sang Bin Baek +7 more
doaj +1 more source
Treatment of rocuronium-induced anaphylaxis using sugammadex - A case report - [PDF]
Anesthesia and Pain Medicine, 2021 Background Perioperative anaphylaxis is a life-threatening clinical condition characterized by severe respiratory and cardiovascular manifestations. Neuromuscular blocking agents are the most common cause of anaphylaxis during anesthesia.
Sun-Min Kim, Sei-hoon Oh, Seung-Ah Ryu
doaj +1 more source
Pharmacological interventions for acceleration of the onset time of rocuronium: a meta-analysis. [PDF]
PLoS ONE, 2014 Rocuronium is an acceptable alternative when succinylcholine is contraindicated for facilitating the endotracheal intubation. However, the onset time of rocuronium for good intubation condition is still slower than that condition of succinylcholine. This
Jing Dong +4 more
doaj +1 more source
The antagonistic effect of neostigmine on rocuronium-, clindamycin-, or both-induced neuromuscular blocking in the rat phrenic nerve-hemidiaphragm [PDF]
Korean Journal of Anesthesiology, 2011 BackgroundNeostigmine augments clindamycin-induced neuromuscular block and antagonizes rocuronium-induced neuromuscular block; however, it remains unclear whether neostigmine enhances the neuromuscular blocking (NMB) that is caused by combinations of ...
Seung Soo Kim +3 more
doaj +1 more source
The effect of long-term oral dantrolene on the neuromuscular action of rocuronium: a case report [PDF]
Korean Journal of Anesthesiology, 2014 Oral dantrolene causes a dose-dependent depression of skeletal muscle contractility. A 52-year-old man treated with oral dantrolene for spasticity after spinal cord injury was scheduled to undergo irrigation and drainage of a thigh abscess under general ...
Jinwoo Jeon +4 more
doaj +1 more source
Comparison of injection pain in pediatric population; original versus generic rocuronium
Saudi Journal of Anaesthesia, 2020 Background: Rocuronium-induced injection pain causes withdrawal movements. These movements may cause accidental disruption of indwelling needles. Generic rocuronium contains low-acid concentration buffer solution compared with original rocuronium.
Fumio Watanabe +2 more
doaj +1 more source