Results 71 to 80 of about 45,078 (254)

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton, Ariane Beauvais, Rebecca Yaworski, Hugh J. McMillan, Rashmi Kothary   +4 more
wiley   +1 more source

Evidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury

Neurobiology of Disease, 2007
We previously reported that cyclophilin A protein is up-regulated in cortical neuronal cultures following several preconditioning treatments. In the present study, we have demonstrated that adenoviral-mediated over-expression of cyclophilin A in rat ...
Sherif Boulos, Bruno P. Meloni, Peter G. Arthur, Bernadette Majda, Christina Bojarski, Neville W. Knuckey   +5 more
doaj   +1 more source

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

The Anatomical Record, EarlyView.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey, Benoît Beyer, Elena García‐Vargas, Isabel Torres‐Sánchez, Francisco García‐Río, Markus Bastir   +5 more
wiley   +1 more source

Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study

Revista Brasileira de Anestesiologia, 2015
BACKGROUND AND OBJECTIVES: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental ...
Angélica de Fátima Braga, Vanessa Henriques Carvalho, Franklin Sarmento Braga, Gloria Maria Braga Potério, Filipe Nadir Caparica Santos   +4 more
doaj   +1 more source

Effects of oropharyngeal neuromuscular stimulation on the volumetric enlarged and reduced tongue base in minipigs

The Anatomical Record, EarlyView.
Abstract Hypoglossal nerve or tongue protruding muscle stimulation is a current treatment option for obstructive sleep apnea. Thus, the present study analyzed 3D deformations of the volumetric enlarged and reduced tongue base upon oropharyngeal neuromuscular stimulation.
Sydney Chen, Doris Haydee Rosero Salazar, Zi‐Jun Liu   +2 more
wiley   +1 more source

Reversal of neuromuscular block after surgical intervention

RUDN Journal of Medicine, 2011
Results of the research on reversal by Neostigmine and suggamadex of neuromuscular block, induced by amino steroid myo-relaxants during emergency surgical interventions. Importance of the neuromuscular monitoring during Anesthesia is discussed.
A V Butrov, M A Magomedov, D M Ribina, E B Alenkina   +3 more
doaj  

Developmental morphology of claspers and clasper‐glands during maturation in Potamotrygon wallacei (Chondrichthyes: Potamotrygoninae)

The Anatomical Record, EarlyView.
Abstract The claspers are the copulatory organs in male elasmobranchs, responsible for directing the semen into the female cloaca (C). However, the microscopic morphology of the claspers remains poorly understood. This study describes the morphology of the claspers and clasper glands (CGs) of cururu stingray (Potamotrygon wallacei) at different ...
Matheus Samuel Cunha Braga, Grazyelle Sebrenski da Silva, Maria Inês Braga de Oliveira, Jaydione Luiz Marcon, Ruben Dario Morales Gamba   +4 more
wiley   +1 more source

Avaliação do bloqueio neuromuscular residual e da recurarização tardia na sala de recuperação pós-anestésica Evaluación del bloqueo neuromuscular residual y de la recurarización tardia en la sala de recuperación pós-anestésica Evaluation of residual neuromuscular block and late recurarization in the post-anesthetic care unit

Revista Brasileira de Anestesiologia, 2004
JUSTIFICATIVA E OBJETIVOS: O bloqueio neuromuscular residual altera a patência das vias aéreas aumentando o risco de graves complicações no pós-operatório.
Maria Cristina Simões de Almeida, Dalto Rodrigues de Camargo, Saul Fernando Linhares, Sérgio Galluf Pederneiras   +3 more
doaj   +1 more source

Human evolution and the obstetrical dilemma: The pelvic floor hypothesis

The Anatomical Record, EarlyView.
Abstract Human childbirth is mechanically difficult because a large‐headed, broad‐shouldered fetus must pass through a comparatively narrow, twisted bony birth canal. Traditional explanations of this “obstetrical dilemma” emphasize the role of bipedal locomotion in inhibiting the evolution of a wider, more spacious pelvis.
Barbara Fischer, Ekaterina Stansfield
wiley   +1 more source

Tracheal intubation without neuromuscular block in children

Indian Journal of Anaesthesia, 2010
Endotracheal intubation has been performed during the administration of Propofol anaesthesia without neuromuscular blockade. In the study, we have assessed tracheal intubating conditions and haemodynamic responses in children aged 4 to12 years by using ...
Safiya I Shaikh, Vijayalaxmi P Bellagali
doaj   +1 more source