Results 81 to 90 of about 1,742,640 (300)

Axial Function Reflects Global Severity in Inherited Ataxias: The Upright Stability Score in Ambulatory Friedreich vs. Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Inherited ataxias are clinically diverse neurodegenerative diseases, complicating the choice of outcome measures for trials. In spinocerebellar ataxia (SCA), regulatory concerns about the Scale for the Assessment and Rating of Ataxia (SARA) caused a shift toward functional SARA (f‐SARA), contributing to pivotal trial failure.
Christian Rummey, S. H. Subramony, David R. Lynch, Louise A. Corben, Martin B. Delatycki, Jörg B. Schulz, Kathrin Reetz, Massimo Pandolfo, Matthis Synofzik, Theresa Zesiewicz, Antoine Duquette, Matthew Burns, Martin Vyhnálek, Lucie Stovickova, Sinead M. Murphy, Petya Bogdanova‐Mihaylova, Mary Kearney, Richard Walsh, Richard H. Roxburgh, Khalaf Bushara, Marie Y. Davis, Enrico S. Bertini, Gessica Vasco, Shweta Sahni, Mohammed Faruq, Achal K. Srivastava, Bart van de Warrenburg, Elisabetta Indelicato, Sylvia Boesch, Andrew Billnitzer, Tetsuo Ashizawa, Anoopum S. Gupta, Grace Yoon, Georgios Koutsis, Chrysoula Koniari, Zofia Fleszar, Christopher M. Gomez, Andrea Martinuzzi, Gabriella Paparella, Ali G. Hamedani, Puneet Opal, Rizwan S. Akhtar, Caterina Mariotti, Henry Paulson, Peter Todd, Sharan R. Srinivasan, George Wilmot, Ludger Schöls, Susan Perlman, Jeremy D. Schmahmann, Sheng‐Han Kuo, Liana S. Rosenthal, Vikram G. Shakkottai   +52 more
wiley   +1 more source

Neuromuscular disorders and sleep

, 2017
This chapter examines the range of sleep disturbances seen in patients with neuromuscular disorders, particularly emphasizing sleep-related breathing disorders which may be a presenting manifestation of neuromuscular disorders, and which significantly ...
Peter Gay, Erik K. St. Louis, Katerina Sajgalikova   +2 more
core   +1 more source

NeuroVisio SyncPatch: A Skin‐Conformal Multimodal EMG–Motion Sensing Platform for Quantitative Neuromuscular Rehabilitation and Performance Monitoring

Advanced Healthcare Materials, EarlyView.
NeuroVisio SyncPatch integrates skin‐conformal electromyography (EMG) electrodes with camera‐tracked markers to jointly assess muscle activity and three‐dimensional knee kinematics during rehabilitation. Parallel feedback pathways provide real‐time kinematic guidance during movement and post‐trial neuromuscular feedback.
Bohyung Choi, Yoo‐Jin Jun, Heewon Choee, Kun‐Do Lee, Heesoo Kim, Yu Seok Hwang, Choong Yeon Kim, Seongok Chae, Juhyun Lee, Minkyu Je, Jae‐Woong Jeong, Hyung‐Soon Park   +11 more
wiley   +1 more source

High‐Density Magnetomyography With Optical Magnetometers Reveals Spatiotemporal Patterns of Evoked Muscle Activity

Advanced Materials Technologies, EarlyView.
Optically pumped magnetometers are employed to contactlessly map the spatiotemporal dynamics of the magnetic field linked to electrical activity of a skeletal muscle in vivo. It is demonstrated that localization of the clinically relevant innervation zone is feasible using this non‐invasive magnetic measurement modality. ABSTRACT Magnetomyography (MMG)
Simon Nordenström, Victor Lebedev, Stefan Hartwig, Marlen Kruse, Santiago Rodriguez, Lukas Baier, Nima Noury, Thomas Klotz, Ahmet Doğukan Keleş, Justus Marquetand, Markus Siegel, Oliver Röhrle, Thomas Middelmann   +12 more
wiley   +1 more source

The European Neuromuscular Centre Consensus Statement on Anaesthesia in Patients with Neuromuscular Disorders.

, 2022
BACKGROUND Patients with neuromuscular conditions are at increased risk of suffering peri-operative complications related to anaesthesia. There is currently little specific anaesthetic guidance concerning these patients.
Løkken, Nicoline, Vilchez, Juan Jesus, Díaz-Cambronero, Óscar, Bastian, Börge, Hellblom, Anna, van den Bersselaar, Luuk R, Reimann, Jens, Hopkins, Philip M, Muenster, Tino, Gillies, Robyn, Klein, Andrea Katharina, Veyckemans, Francis, Litman, Ron, Snoeck, Marc M J, Tasca, Giorgio, Riazi, Sheila, Heytens, Luc, Silva, Helga C A, Rueffert, Henrik, Voermans, Nicol C, Jungbluth, Heinz, Johannsen, Stephan   +21 more
core   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations [PDF]

Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood.
Çavdarlı, Büşranur, Yareeda, Sireesha, Wilmshurst, Jo, Vengalil, Seena, Smuts, Izelle, Köken, Özlem Yayıcı, Sobreira, Claudia F. R., Horvath, Rita, Polat, Ipek, van der Westhuizen, Francois H, Baskar, Dipti, Vandrovcova, Jana, Hanna, Michael G, Bearden, David, Naidu, Kireshnee, Rani, Nimita, Schoonen, Maryke, Schon, Katherine R, Vishnu, Venugopalan Y, Tomaselli, Pedro, Topoloğlu, Haluk, Raga, Sharika, Nalini, Atchayaram, Wilson, Lindsay A, Marques, Wilson, Meldau, Surita, Gao, Fei, Nandeesh, Bevinahalli N, Henning, Franclo, Chinnery, Patrick F, Yiş, Uluç, Heckmann, Jeannine, Thangaraj, Kumarasamy, Kvalsund, Michelle, Kapapa, Musambo   +34 more
core   +4 more sources

Experiences of attendance at a neuromuscular centre: perceptions of adults with neuromuscular disorders [PDF]

, 2011
PURPOSE: The aim of this research is to gain an insight into adults with neuromuscular disorders' experiences of attendance at a specialised, voluntary sector, Neuromuscular Centre and explore its value to these adults who attend for treatment, education
Hartley, SE, Juliet Goldbart, Peter Charles Goodwin, Goodwin, PC, Goldbart, J, Sandra Elaine Hartley   +5 more
core   +2 more sources