Results 91 to 100 of about 59,298 (301)
Identification and characterization of agrin in "Caenorhabditis elegans" [PDF]
, 2006 Agrin is a large basement membrane (BM) proteoglycan expressed in many tissues in vertebrates, with particularly important function at the neuromuscular junction (NMJ) where it clusters acetylcholine receptors (AChRs) and maintains structural stability ...
Hrus, Ana
core +1 more source
alpha-Actinin interacts with rapsyn in agrin-stimulated AChR clustering
Molecular Brain, 2008 AChR is concentrated at the postjunctional membrane at the neuromuscular junction. However, the underlying mechanism is unclear. We show that α-actinin, a protein known to cross-link F-actin, interacts with rapsyn, a scaffold protein essential for ...
Dobbins G Clement +4 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Abstract Background Ex vivo lung perfusion (EVLP) allows the evaluation of lungs that do not meet standard transplantation criteria. Current procedures do not permit the identification of regional functional deficits. We investigated the feasibility of assessing lobar gas exchange during EVLP in a swine model.
Giulia Maria Ruggeri +16 more
wiley +1 more source
Neuromuscular junction signalling [PDF]
, 2009 A Powerpoint slide of an animated cartoon of acetylcholine signal transmission at a neuromuscular ...
Verna Lavender
core
F1000Research, 2016 Myasthenia gravis is an autoimmune disease of the neuromuscular junction (NMJ) caused by antibodies that attack components of the postsynaptic membrane, impair neuromuscular transmission, and lead to weakness and fatigue of skeletal muscle.
William D. Phillips, Angela Vincent
doaj +1 more source
Annals of Neurology, EarlyView.Objectives Nerve transfer is a promising intervention for restoring hand and upper limb function after cervical spinal cord injury (SCI), but the timeline of neurophysiological recovery in humans remains unclear. This study aimed to define recovery profiles after nerve transfers to restore upper limb function.
Kyle J. Missen +14 more
wiley +1 more source
Pathophysiological associations in paediatric neuromuscular junction disorders [PDF]
, 2017 Myasthenia can be caused by acquired or autoimmune conditions and other conditions resulting from genetic abnormalities of the proteins in the neuromuscular junction.
Matthew Pitt
core +1 more source
Annals of Neurology, EarlyView.Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton +4 more
wiley +1 more source
Capsaicin protects neuromuscular junctions from the inhibitory effects of botulinum neurotoxin A [PDF]
, 2008 Within 24 hrs after injecting botulinum neurotoxin A (BoNT/A) into the hindlimb, mice lost the toe spread reflex and developed progressive muscle weakness. At the same time, the compound muscle action potential amplitude decreased. Injection of capsaicin
Carmen Garcia +5 more
core +1 more source
Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome
Case Reports in Neurological Medicine, 2016 Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of
Stéphane Mathis +7 more
doaj +1 more source