Results 161 to 170 of about 4,568,978 (366)

Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3‐deficient muscular dystrophy

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp   +12 more
wiley   +1 more source

Electrical Impedance Myography Detects Disease Progression over 12 to 24 Months in Facioscapulohumeral Muscular Dystrophy

open access: yesAnnals of Neurology, EarlyView.
Objective Targeted therapies for facioscapulohumeral muscular dystrophy (FSHD) are progressing through clinical trials. Electrical impedance myography (EIM) provides a noninvasive biomarker of muscle composition that may be valuable especially in early phase trials. This study evaluated EIM data from a multicenter FSHD cohort over 24 months.
Karlien Mul   +15 more
wiley   +1 more source

The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy

open access: yesAnnals of Neurology, EarlyView.
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva   +13 more
wiley   +1 more source

Minimalist Footwear Acutely Alters Running Kinematics in Runners With Medial Tibial Stress Syndrome

open access: yesArthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To assess immediate biomechanical changes in runners with medial tibial stress syndrome (MTSS) when transitioning from standard to minimalist running shoes. Methods Active runners diagnosed with MTSS ran on a treadmill at 10 km/h using standard and minimalist running shoes. Hip, knee, and ankle joint kinematics were captured using a 16‐infrared‐
Quyet Thang Nguyen   +6 more
wiley   +1 more source

Anterior Capsular Reconstruction With Dermal Allograft Augmentation for Multidirectional Shoulder Instability

open access: yesArthroscopy Techniques, EarlyView.
Abstract Multidirectional shoulder instability, particularly in patients with underlying connective tissue disorders poses a surgical challenge. After exhaustive nonoperative treatment, surgical intervention is focused on restoration of the anterior and inferior capsular restraints.
Mikalyn T. DeFoor   +6 more
wiley   +1 more source

Neuromuscular block monitoring by smartphone application (i-TOF© system): an observational pilot study [PDF]

open access: gold, 2020
Lorenzo Schiavoni   +3 more
openalex   +1 more source

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