Results 201 to 210 of about 4,568,978 (366)

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan   +20 more
wiley   +1 more source

Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Despite advancements in “autoimmune epilepsy,” more accurately referred to herein as seizures or epilepsy of autoimmune etiology, significant variability exists in its recognition, diagnosis, and management internationally. This study assessed clinicians' understanding, access to diagnostic tools, and treatment practices across ...
Emily Guarasci   +3 more
wiley   +1 more source

Reversal of neuromuscular block after surgical intervention

open access: yesRUDN Journal of Medicine, 2011
Results of the research on reversal by Neostigmine and suggamadex of neuromuscular block, induced by amino steroid myo-relaxants during emergency surgical interventions. Importance of the neuromuscular monitoring during Anesthesia is discussed.
A V Butrov   +3 more
doaj  

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

open access: yesEnvironmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz   +9 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska   +4 more
wiley   +1 more source

A Prediction Model for One‐Year Disability Risk Among Community‐Dwelling Older Adults in China: Integrating Physical, Metabolic, and Psychosocial Factors

open access: yesHealth Care Science, EarlyView.
Based on a prospective cohort of 1003 older adults, we developed and validated a practical disability prediction model integrating physical, metabolic, and psychosocial factors (AUC = 0.716), presented via a user‐friendly nomogram for community use. ABSTRACT Background Disability in older adults, characterized by progressive limitations in performing ...
Yanjun Ma   +8 more
wiley   +1 more source

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