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Nrf2 promotes neuronal cell differentiation [PDF]

open access: yesFree Radical Biology and Medicine, 2009
The transcription factor Nrf2 has emerged as a master regulator of the endogenous antioxidant response, which is critical in defending cells against environmental insults and in maintaining intracellular redox balance. However, whether Nrf2 has any role in neuronal cell differentiation is largely unknown. In this report, we have examined the effects of
Fei Zhao, Tongde Wu, Weimin Chen
exaly   +3 more sources
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Transglutaminase and neuronal differentiation

Molecular and Cellular Biochemistry, 1986
During mouse brain maturation cellular transglutaminase specific activity increases 2.5 fold from day 3 to adulthood. A more pronounced increase is seen during morphological differentiation of mouse neuroblastoma cells, where serum withdrawal induces neurite outgrowth concomitant with a 10 fold increase in transglutaminase specific activity.
R B, Maccioni, N W, Seeds
openaire   +2 more sources

Gangliosides and neuronal differentiation

Neurochemistry International, 1992
Using the GD3-specific mAb R24 we demonstrate by immunohistochemistry that the first embryonic cells of chicken expressing GD3 represent heavily proliferating cells of mesodermal origin (mesenchymal stem and endothelial cells). At this developmental stage (E1-1.5) neuroectodermal cells of the forming neural tube are not stained by R24 or any other ...
H, Rösner, M, al-Aqtum, H, Rahmann
openaire   +2 more sources

AUTS2 isoforms control neuronal differentiation

Molecular Psychiatry, 2019
Mutations in AUTS2 are associated with autism, intellectual disability, and microcephaly. AUTS2 is expressed in the brain and interacts with polycomb proteins, yet it is still unclear how mutations in AUTS2 lead to neurodevelopmental phenotypes. Here we report that when neuronal differentiation is initiated, there is a shift in expression from a long ...
Monderer-Rothkoff, Galya   +9 more
openaire   +3 more sources

Glial Tumors with Neuronal Differentiation

Neurosurgery Clinics of North America, 2015
Immunohistochemical studies for neuronal differentiation in glial tumors revealed subsets of tumors having both characteristics of glial and neuronal lineages. Glial tumors with neuronal differentiation can be observed with diverse phenotypes and histologic grades.
Chul-Kee, Park   +2 more
openaire   +2 more sources

Neuronal differentiation in C. elegans

Current Opinion in Cell Biology, 2005
The small size and defined connectivity of the C. elegans nervous system and the amenability of this species to systematic functional screens have continued to yield new insights into neuronal differentiation. Many aspects of C. elegans neuronal development resemble those of other more complex neurons.
Andrew D, Chisholm, Yishi, Jin
openaire   +2 more sources

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