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This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang +10 more
wiley +1 more source
A conformal ALD‐IGZO vertical RRAM integrates volatile and nonvolatile switching within a compact 2F architecture. Before forming, tunable volatile dynamics provide fading‐memory reservoir states, while after forming, stable multilevel conductance modulation enables hardware readout.
Seeun Lee +6 more
wiley +1 more source
Neuronal Migration and AUTS2 Syndrome [PDF]
Neuronal migration is one of the pivotal steps to form a functional brain, and disorganization of this process is believed to underlie the pathology of psychiatric disorders including schizophrenia, autism spectrum disorders (ASD) and epilepsy. However, it is not clear how abnormal neuronal migration causes mental dysfunction.
Kei Hori, Mikio Hoshino
exaly +4 more sources
New Trends in Neuronal Migration Disorders
Neuronal migration disorders are an heterogeneous group of disorders of nervous system development and they are considered to be one of the most significant causes of neurological and developmental disabilities and epileptic seizures in childhood. In the
Alberto Verrotti +2 more
exaly +3 more sources
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Mental Retardation and Developmental Disabilities Research Reviews, 2001
AbstractNeuronal migration disorders are a category of developmental brain disorders leading to cortical dysplasia. This group of disorders is characterized by defective movement of neurons from the place of origin along the lining of the lateral ventricle, to the eventual place of residence in the correct laminar position within the cerebral cortex ...
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AbstractNeuronal migration disorders are a category of developmental brain disorders leading to cortical dysplasia. This group of disorders is characterized by defective movement of neurons from the place of origin along the lining of the lateral ventricle, to the eventual place of residence in the correct laminar position within the cerebral cortex ...
openaire +2 more sources
The Dynamics of Neuronal Migration
2013Proper lamination of the cerebral cortex is precisely orchestrated, especially when neurons migrate from their place of birth to their final destination. The consequences of failure or delay in neuronal migration cause a wide range of disorders, such as lissencephaly, schizophrenia, autism and mental retardation. Neuronal migration is a dynamic process,
Qian, Wu +6 more
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Endocannabinoid signalling in neuronal migration
The International Journal of Biochemistry & Cell Biology, 2014The endocannabinoid (eCB) system consists of several endogenous lipids, their target CB1 and CB2 receptors and enzymes responsible for their synthesis and degradation. The most abundant eCB in the central nervous system (CNS), 2-arachidonoyl glycerol (2-AG), triggers a broad range of signalling events by acting on CB1, the most abundant G protein ...
Zhou, Ya +2 more
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Neuronal migration on laminin in vitro
Developmental Brain Research, 1992Chick sympathetic (E-9) or telencephalic (E-7) neurons were cultured at low density on poly-DL-ornithine (PORN), poly-L-lysine (POLS), laminin or laminin-covered PORN or POLS and monitored with time-lapse videomicroscopy. Neurons migrated on laminin, or laminin-covered PORN or POLS, but not on PORN or POLS alone.
S, Liang, K A, Crutcher
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Taurine Deficiency and Neuronal Migration
1996Cerebellar granule neurons migrate from the external layer to the internal granule layer along the processes of Bergmann fibers14, 15. It is known from a number of studies that this is a finely modulated process of cell-cell interaction controlled by a variety of external conditions.
J, Morán +5 more
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Neuronal growth cone migration
Experientia, 1990The neuronal growth cone is a semi-autonomous portion of the developing neuron that is highly specialized for motile activity. Migrating neurons may share some features with neuronal growth cones. I review some of what has been learned about growth cone initiation, the differentiation of axons and dendrites, the role of the cytoskeleton in motility ...
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