Results 121 to 130 of about 1,753,121 (371)

BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities

open access: yeseLife, 2017
The Bone Morphogenetic Protein (BMP) family reiteratively signals to direct disparate cellular fates throughout embryogenesis. In the developing dorsal spinal cord, multiple BMPs are required to specify sensory interneurons (INs).
Madeline G Andrews   +5 more
doaj   +1 more source

Machine learning based radiomics model to predict radiotherapy induced cardiotoxicity in breast cancer

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Cardiotoxicity is one of the major concerns in breast cancer treatment, significantly affecting patient outcomes. To improve the likelihood of favorable outcomes for breast cancer survivors, it is essential to carefully balance the potential advantages of treatment methods with the risks of harm to healthy tissues, including the heart.
Amin Talebi   +6 more
wiley   +1 more source

Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells

open access: yesBiological Research, 2004
Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals.
MARÍA ANGÉLICA CARRASCO   +3 more
doaj  

Detecting Neurodevelopmental Toxicity of Domoic Acid and Ochratoxin A Using Rat Fetal Neural Stem Cells

open access: yesMarine Drugs, 2019
Currently, animal experiments in rodents are the gold standard for developmental neurotoxicity (DNT) investigations; however, testing guidelines for these experiments are insufficient in terms of animal use, time, and costs.
Santokh Gill, V. M. Ruvin Kumara
doaj   +1 more source

Inference based method for realignment of single trial neuronal responses [PDF]

open access: yesarXiv, 2015
Neuronal responses to sensory stimuli or neuronal responses related to behaviour are often extracted by averaging neuronal activity over large number of experimental trials. Such trial-averaging is carried out to reduce noise and to reduce the influence of other signals unrelated to the corresponding stimulus or behaviour.
arxiv  

Neuronal Development: Putting Motor Neurons in Their Place [PDF]

open access: yesCurrent Biology, 2004
In the developing spinal cord, motor neurons occupy discrete columns with different identities and axon projections. This organisation has now been shown to depend crucially on sequential phases of expression of Hox-c proteins, generated in response to fibroblast growth factor signals.
openaire   +4 more sources

Evaluation of AI‐based auto‐contouring tools in radiotherapy: A single‐institution study

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Accurate delineation of organs at risk (OARs) is crucial yet time‐consuming in the radiotherapy treatment planning workflow. Modern artificial intelligence (AI) technologies had made automation of OAR contouring feasible. This report details a single institution's experience in evaluating two commercial auto‐contouring software ...
Tingyu Wang   +10 more
wiley   +1 more source

Unsupervised learning by a nonlinear network with Hebbian excitatory and anti-Hebbian inhibitory neurons [PDF]

open access: yesarXiv, 2018
This paper introduces a rate-based nonlinear neural network in which excitatory (E) neurons receive feedforward excitation from sensory (S) neurons, and inhibit each other through disynaptic pathways mediated by inhibitory (I) interneurons. Correlation-based plasticity of disynaptic inhibition serves to incompletely decorrelate E neuron activity ...
arxiv  

Enhanced dose prediction for head and neck cancer artificial intelligence‐driven radiotherapy based on transfer learning with limited training data

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Training deep learning dose prediction models for the latest cutting‐edge radiotherapy techniques, such as AI‐based nodal radiotherapy (AINRT) and Daily Adaptive AI‐based nodal radiotherapy (DA‐AINRT), is challenging due to limited data.
Hui‐Ju Wang   +5 more
wiley   +1 more source

Cytochrome c Oxidase on the Crossroads of Transcriptional Regulation and Bioenergetics

open access: yesFrontiers in Physiology, 2019
Mitochondria are the organelles of eukaryotic cells responsible for the ATP production by means of the electron transfer chain (ETC). Its work is under strict genetic control providing the correct assembly of the enzyme complexes and the interface to ...
Ivan Vladimirovich Chicherin   +7 more
doaj   +1 more source

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