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A spinal microglia population involved in remitting and relapsing neuropathic pain
Science, 2022Neuropathic pain is often caused by injury and diseases that affect the somatosensory system. Although pain development has been well studied, pain recovery mechanisms remain largely unknown.
Keita Kohno +10 more
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Neuropathic pain: From mechanisms to treatment.
Physiological Reviews, 2020Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition with major impact on quality of life.
N. Finnerup, R. Kuner, T. Jensen
semanticscholar +1 more source
2023
Neuropathic pain is one of the most frequent symptoms in neurological clinical practice. It is caused by a lesion or disease of the somatosensory system and encompasses a broad spectrum of pathologies ranging from peripheral polyneuropathies to central nervous system disorders.
Rocchi C., Valeriani M., Leo R. D.
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Neuropathic pain is one of the most frequent symptoms in neurological clinical practice. It is caused by a lesion or disease of the somatosensory system and encompasses a broad spectrum of pathologies ranging from peripheral polyneuropathies to central nervous system disorders.
Rocchi C., Valeriani M., Leo R. D.
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Pain, 2020
The inflammatory/immune response at the site of peripheral nerve injury participates in the pathophysiology of neuropathic pain. Nevertheless, little is known about the local regulatory mechanisms underlying peripheral nerve injury that counteract the ...
Marcela Davoli-Ferreira +10 more
semanticscholar +1 more source
The inflammatory/immune response at the site of peripheral nerve injury participates in the pathophysiology of neuropathic pain. Nevertheless, little is known about the local regulatory mechanisms underlying peripheral nerve injury that counteract the ...
Marcela Davoli-Ferreira +10 more
semanticscholar +1 more source
Hospital Medicine, 2000
Neuropathic pain is a distressing, poorly understood and under-treated condition. In this review we seek to examine the definition and classification of neuropathic pain, summarize clinically important underlying mechanisms, outline current management strategies and look at future directions for research and therapy.
T E, Smith, M S, Chong
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Neuropathic pain is a distressing, poorly understood and under-treated condition. In this review we seek to examine the definition and classification of neuropathic pain, summarize clinically important underlying mechanisms, outline current management strategies and look at future directions for research and therapy.
T E, Smith, M S, Chong
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Seminars in Neurology, 2021
AbstractNeuropathic pain is a common chief complaint encountered by neurologists and primary care providers. It is caused by disorders involving the somatosensory nervous system. The clinical evaluation of neuropathic pain is challenging and requires a multifaceted systematic approach with an emphasis on a thorough history and physical examination to ...
Ashwin Malhotra, Joshua Weaver
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AbstractNeuropathic pain is a common chief complaint encountered by neurologists and primary care providers. It is caused by disorders involving the somatosensory nervous system. The clinical evaluation of neuropathic pain is challenging and requires a multifaceted systematic approach with an emphasis on a thorough history and physical examination to ...
Ashwin Malhotra, Joshua Weaver
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Current Opinion in Neurology, 2001
Damage to peripheral nerves triggers a cascade of events in axotomized sensory neurones that are generally believed to be responsible for the generation of neuropathic pain. Recent data in animal models show that alterations in the properties of undamaged neurones that project into a damaged nerve can also play an important role.
M, Koltzenburg, J, Scadding
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Damage to peripheral nerves triggers a cascade of events in axotomized sensory neurones that are generally believed to be responsible for the generation of neuropathic pain. Recent data in animal models show that alterations in the properties of undamaged neurones that project into a damaged nerve can also play an important role.
M, Koltzenburg, J, Scadding
openaire +2 more sources
Understanding Neuropathic Pain
CNS Spectrums, 2005AbstractNeuropathic pain is defined as a chronic pain condition that occurs or persists after a primary lesion or dysfunction of the peripheral or central nervous system. Traumatic injury of peripheral nerves also increases the excitability of nociceptors in and around nerve trunks and involves components released from nerve terminals (neurogenic ...
Walter, Zieglgänsberger +2 more
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2013
Neuropathic pain is a clinical entity that presents unique diagnostic and therapeutic challenges. This chapter addresses the classification, epidemiology, pathophysiology, diagnosis, and treatment of neuropathic pain syndrome. Neuropathic pain can be distinguished from nociceptive pain based on clinical signs and symptoms.
Eric, Kerstman +4 more
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Neuropathic pain is a clinical entity that presents unique diagnostic and therapeutic challenges. This chapter addresses the classification, epidemiology, pathophysiology, diagnosis, and treatment of neuropathic pain syndrome. Neuropathic pain can be distinguished from nociceptive pain based on clinical signs and symptoms.
Eric, Kerstman +4 more
openaire +2 more sources
Epidemiology of Neuropathic Pain
Pain Management, 2010Epidemiology is an essential clinical tool in designing and evaluating management and prevention strategies, and is particularly relevant to neuropathic pain. Despite its relevance to neuropathic pain however, there is a paucity of accurate information on its prevalence, distribution and determinants, for several reasons.
Blair H, Smith, Nicola, Torrance
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