Results 121 to 130 of about 805 (153)

Neuropathogenic and non-neuropathogenic variants of equine herpesvirus 1 in France

Veterinary Microbiology, 2010
Equine herpesvirus 1 (EHV-1) is a common pathogen of the horse which may induce mild respiratory distress, abortion, neonatal death and neurological disease. A single nucleotide polymorphism in the EHV-1 DNA polymerase (ORF30 A(2254) to G(2254)) has been associated with clinical signs of Equine herpes myeloencephalopathy (EHM). The aim of this work was
Pronost, Stéphane, Léon, Albertine, Legrand, Loïc, Fortier, Christine, Miszczak, Fabien, Freymuth, François, Fortier, Guillaume   +6 more
openaire   +3 more sources

Neuropathogenic and non-neuropathogenic genotypes of Equid Herpesvirus type 1 in Argentina

Veterinary Microbiology, 2009
Infection with Equid Herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurological disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism (A(2254)/G(2254)) in the genome region of the open reading frame 30 (ORF30), which results in an amino acid variation (N(752)/D(752)) of the ...
M A, Vissani, M L, Becerra, C, Olguín Perglione, M S, Tordoya, S, Miño, M, Barrandeguy   +5 more
openaire   +2 more sources

The neuropathogenic contributions of lysosomal dysfunction

Journal of Neurochemistry, 2002
AbstractMultiple lines of evidence implicate lysosomes in a variety of pathogenic events that produce neurodegeneration. Genetic mutations that cause specific enzyme deficiencies account for more than 40 lysosomal storage disorders. These mostly pre‐adult diseases are associated with abnormal brain development and mental retardation. Such disorders are
Ben A, Bahr, Jennifer, Bendiske
openaire   +2 more sources

Neuropathogenicity of Equine Herpesvirus 9 in Cattle

Journal of Equine Veterinary Science, 2011
Abstract The pathogenicity of equine herpesvirus 9 (EHV-9), a neurotropic equine herpesvirus isolated from a herd of Gazella thomsoni, was studied in cattle. Seven calves were inoculated intranasally with 105 and 107 plaque-forming units of the EHV-9 P19.
Nagwan El-Habashi, El-Shaymaa El-Nahass, Hideto Fukushi   +2 more
exaly   +2 more sources

Neuropathogenicity of measles virus

1978
K B Fraser, S J Martin
exaly   +2 more sources

Hypothermia and Alzheimers Disease Neuropathogenic Pathways

Current Alzheimer Research, 2010
Alzheimer's disease (AD) remains a major health problem, and accounts for 50 to 60% of all cases of dementia. The two histopathological hallmarks of AD are senile plaques, composed of the β-amyloid peptide (Aβ), and intraneuronal neurofibrillary tangles composed of abnormally hyperphosphorylated tau protein.
R A, Whittington, M-A, Papon, F, Chouinard, E, Planel   +3 more
openaire   +2 more sources

Neuropathogenic Viruses and Immunity

Archives of Neurology, 1994
Neuropathogenic Viruses and Immunity , edited by Specter, Bendinelli, and Friedman and a volume in the series entitled Infectious Agents and Pathogenesis , represents a comprehensive review of neurovirology written by more than 30 distinguished neuroscientists. Divided into four sections, "General Information," "Animal Models," "Human Infections of the
openaire   +1 more source

Immunogenic determinants of a neuropathogenic murine leukemia virus

Journal of Virology, 1995
Previous studies of Cas-Br-M murine leukemia virus (MuLV) (Cas-MuLV) infection demonstrated that cytotoxic T cells (CTL) of the CD8+ phenotype play a role in resistance to the neuropathogenic effects of the virus in NFS/N mice. In the current study, we sought to identify the Cas-MuLV epitopes that are immunogenic for the CTL response.
D S, Robbins, M P, Remington, M, Sarzotti, D, St Louis, P M, Hoffman   +4 more
openaire   +2 more sources

High incidence of meningeal infiltration by leukemic cells after infection of chimeric virus between neuropathogenic and non-neuropathogenic retroviruses

Journal of Neurovirology, 1999
Friend murine leukemia virus (F-MuLV) clone A8, previously shown to cause spongiform degeneration in rat brain, induced leukemia within 10 weeks after infection when inoculated into newborn rats. The chimeric virus Rec2, which contains the pol and env genes of 57 virus on the background of A8 and does not cause spongiform degeneration in the central ...
S, Takase-Yoden, R, Watanabe
openaire   +2 more sources

The peripheral immune response of mice infected with a neuropathogenic schistosome

Parasite Immunology, 2020
AbstractTrichobilharzia regenti (Schistosomatidae) percutaneously infects birds and mammals and invades their central nervous system (CNS). Here, we characterized the peripheral immune response of infected mice and showed how it was influenced by the parasite‐induced inflammation in the skin and the CNS.
Martin Majer, Tomáš Macháček, Lenka Súkeníková, Jiří Hrdý, Petr Horák   +4 more
openaire   +2 more sources