Results 61 to 70 of about 513,228 (356)

Diabetic Neuropathies [PDF]

Seminars in Neurology, 2015
Diabetes mellitus is a common condition and diabetics are prone to develop a spectrum of neuropathic complications ranging from symmetric and diffuse to asymmetric and focal neuropathies that may be associated with significant morbidity. Diabetic sensorimotor polyneuropathy is the most common of these complications, occurring in patients with type 1 ...
Aaron, Izenberg, Bruce A, Perkins, Vera, Bril   +2 more
openaire   +2 more sources

Autosomal Recessive Spastic Ataxia of Charlevoix‐Saguenay in Two Half‐Siblings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Autosomal recessive spastic ataxia of Charlevoix‐Saguenay (ARSACS) is caused by biallelic pathogenic variants in the SACS gene. We report the clinical, radiologic and neurophysiologic features of a pair of half‐siblings who presented with progressive cerebellar ataxia, peripheral neuropathy and upper motor neuron signs.
Dennis Yeow, Matthew Katz, Jonathan Rodgers, Mark Davis, Thomas Robertson, R. J. McKinlay Gardner, Pamela A. McCombe   +6 more
wiley   +1 more source

MicroRNA 200c-3p regulates autophagy via upregulation of endoplasmic reticulum stress in PC-3 cells

Cancer Cell International, 2018
Background Autophagy is a response to cellular and environmental conditions and facilitates cell survival. Here, we investigated the role of ectopic expression of microRNA (miRNA) 200c-3p in autophagy. Methods miRNA mimics were used to overexpress miRNAs.
Eun Jung Sohn
doaj   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Transcriptional Fingerprint of Hypomyelination in and () Mice

ASN Neuro, 2016
The transcriptional program that controls oligodendrocyte maturation and central nervous system (CNS) myelination has not been fully characterized. In this study, we use high-throughput RNA sequencing to analyze how the loss of a key transcription factor,
Joshua D. Aaker, Benayahu Elbaz, Yuwen Wu, Timothy J. Looney, Li Zhang, Bruce T. Lahn, Brian Popko   +6 more
doaj   +1 more source

Neuropathy - gait changes in the diabetic foot [PDF]

, 2008
Motor neuropathy in patients with diabetes can lead to weakness in the muscles of the foot and lower leg, which in turn can lead to characteristic changes to the structure of the foot, such as an altered arch profile.
McIntosh, Caroline, Newton, Veronica
core  

Teleneurology clinics for polyneuropathy: a pilot study. [PDF]

, 2020
INTRODUCTION:Polyneuropathy (PN) is a common condition with significant morbidity. We developed tele-polyneuropathy (tele-PN) clinics to improve access to neurology and increase guideline-concordant PN care.
Cheng, Eric M, Hanssen, Andrea, Inkelas, Moira, Jamal, Nasheed I, Ong, Michael K, Saliba, Debra, Torres, Jorge A, Wilson, Andrew M   +7 more
core  

Minimal clinically important difference of the EORTC QLQ-CIPN20 for worsening peripheral neuropathy in patients receiving neurotoxic chemotherapy. [PDF]

, 2019
Context/objectivesThis is the first study to determine the minimal clinically important difference (MCID) of the European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-CIPN twenty-item scale (EORTC QLQ-CIPN20), a ...
Ang, Emily, Au, Joseph SK, Bandla, Aishwarya, Chan, Alexandre, Chan, Choi Wan, Cheng, Hui Lin, Farrell, Carole, Leung, Kwun To, Li, Yu Chung, Loh, Kiley WJ, Lopez, Violeta, Molassiotis, Alex, Ng, Chiu Chin, Suen, Lorna, Sundar, Raghav, Wong, Kam-Hung, Yeo, Fiona, Yorke, Janelle   +17 more
core   +3 more sources

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Correlates of calcaneal quantitative ultrasound parameters in patients with diabetes: the study on the assessment of determinants of muscle and bone strength abnormalities in diabetes [PDF]

, 2017
OBJECTIVE: Quantitative ultrasound (QUS) provides an estimate of bone mineral density (BMD) and also evaluates bone quality, which has been related to increased fracture risk in people with diabetes.
Alessi, Elena, Balducci, Stefano, Bollanti, Lucilla, Conti, Francesco, D'Errico, Valeria, Iacobini, Carla, Menini, Stefano, Nicolucci, Antonio, Pugliese, Giuseppe, Pugliese, Luca, Salerno, Gerardo, Vitale, Martina   +11 more
core   +2 more sources