Results 121 to 130 of about 28,987 (259)

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

open access: yesEpilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen   +15 more
wiley   +1 more source

Are comorbid sleep disorders associated with higher risk for sudden unexpected death in epilepsy? Observations from a Canadian epilepsy clinic

open access: yesEpilepsia, EarlyView.
Abstract Objective Pooled mortality is nearly three times higher in people with epilepsy (PWE). Approximately 80% of sudden unexpected death in epilepsy (SUDEP) events occur during sleep, and primary sleep disorders are prevalent in the general population and PWE.
Marion Lazaj   +7 more
wiley   +1 more source

Intraoperative neurophysiological monitoring in surgery for intramedullary spinal cord lesions - workflow, setup and outcomes. [PDF]

open access: yesActa Neurochir (Wien)
Frisk H   +12 more
europepmc   +1 more source

Presurgical magnetoencephalography‐derived network control metrics distinguish successful hippocampal resection vs sparing in temporal lobe epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Surgical decision‐making in temporal lobe epilepsy (TLE) faces a critical challenge in determining whether the hippocampus can be safely spared during anterior temporal resection, particularly when surgery involves the language‐dominant hemisphere.
Guhan Seshadri NP   +6 more
wiley   +1 more source

Pediatric epilepsy surgery: Global survey of invasive explorations

open access: yesEpilepsia, EarlyView.
Abstract Objective Invasive presurgical evaluation plays a key role in pediatric epilepsy surgery, particularly in magnetic resonance imaging (MRI)‐negative cases, by guiding resective, disconnective, or ablative procedures. This International League Against Epilepsy (ILAE) Pediatric Epilepsy Surgery Taskforce study provides an updated global overview ...
Georgia Ramantani   +96 more
wiley   +1 more source

Intraoperative neurophysiological monitoring for motor function preservation during AVMs resection: Indication or redundancy? Beyond the doctrine of "all-or-nothing". [PDF]

open access: yesNeurosurg Rev
Sturiale CL   +8 more
europepmc   +1 more source

Diagnosis and management guidelines for infantile epileptic spasms syndrome around the world: A scoping review and comparative study of international approaches

open access: yesEpilepsia, EarlyView.
Abstract Objective Infantile epileptic spasms syndrome (IESS) is an epileptic encephalopathy requiring rapid diagnosis and treatment to optimize neurodevelopmental outcomes. Although multiple national and regional guidelines exist, recommendations vary.
Gozde Erdemir   +21 more
wiley   +1 more source

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