Quantitative EEG obtained from Dual‐Task paradigms for the study of preclinical populations at risk of Alzheimer Disease [PDF]
Abstract Background Colombia hosts the largest Autosomal‐Dominant Alzheimer's Disease (ADAD) kindred caused by the PSEN1‐E280A genetic variant, with full penetrance. This ADAD is well‐characterized in terms of clinical and biomarker research, but Electroencephalography (EEG) as a biomarker is still under development. EEG facilitates understanding brain
Rada J +6 more
europepmc +4 more sources
Betweenness centrality as neurophysiological marker of DMN functional connectivity in asymptomatic carriers of PSEN1 E280A for ADAD [PDF]
Abstract Background Graph metrics have been used to evaluate functional connectivity in Alzheimer's disease (AD). It has been found that nodal and global graph metrics are altered in subjects with AD and MCI compared to controls. In subjects with mutations associated with autosomal dominant Alzheimer's disease (ADAD), these metrics may vary depending ...
Aponte C +6 more
europepmc +2 more sources
Mega‐Analysis of Oscillatory and Aperiodic Resting‐State EEG Alterations in Neurodegenerative Diseases [PDF]
Abstract Background Resting‐state EEG (rsEEG) alterations in the posterior alpha rhythm are promising biomarkers of neurodegenerative diseases (NDDs). However, spectral analysis often overlooks the rsEEG non‐rhythmic (aperiodic) component. Studies assessing the oscillatory and aperiodic activity are scarce and frequently underpowered. While multicenter
Jaramillo‐Jimenez A +14 more
europepmc +2 more sources
The effect of cumulative trauma and polarised thinking on severity of depressive disorder. [PDF]
Abstract Over recent decades, there has been more evidence of the connection between trauma and depression. More research is needed on the relationship between different types of trauma and their combination (cumulative trauma) with respect to the severity of depressive symptoms.
Salla M +4 more
europepmc +2 more sources
Periodic and Aperiodic EEG Parameters During Transitions from Wakefulness to Light Sleep: Preliminary Results on Patients with Mild Cognitive Impairment Due to Alzheimer's Disease vs. Healthy Elderly [PDF]
Abstract Background The periodic (e.g., EEG alpha power density) and aperiodic (offset and slope of EEG power density) components of resting‐state EEG rhythms reflect different aspects of global neural dynamics and have been linked to excitatory/inhibitory balance.
Carpi M +13 more
europepmc +2 more sources
Can Yerba Mate Reduce the Risk of Cognitive Impairment? A pilot study [PDF]
Abstract Background Yerba mate (YM), an infusion made from Ilex paraguariensis, is widely consumed in Argentina and other South American countries. Experimental studies have shown that YM enhances antioxidant defenses, increases chaperonin expression, and reduces AChE activity and Aβ expression.
Gilbert A +15 more
europepmc +2 more sources
Baseline Results Investigate APOE‐Memory Connection in Latin‐American Population at Risk for Dementia ‐ LatAm‐FINGERS Initial Insights [PDF]
Abstract Background Latin America (LA) faces heightened vulnerability to modifiable dementia risk factors. Early identification of at‐risk individuals is crucial for implementing effective preventive strategies. The Free and Cued Selective Reminding Test with Immediate Recall (FCSRT‐IR) is promising in early detection of mnemonic impairment, with high ...
Friedlaender C +45 more
europepmc +2 more sources
Executive Functions in Latin American Older Adults: Exploring the Concept Shifting Test and Its Relationship with the APOE Gene in a Cross‐Sectional Sample from the LatAm‐FINGERS Study [PDF]
Abstract Background Latin America (LA) faces high vulnerability to dementia risk factors. Early detection of cognitive decline, particularly in executive functions (EF), is crucial. The Trail Making Test (TMT) has limitations, while the Concept Shifting Test (CST) offers potential advantages but lacks LA adaptation.
Cardoso D +45 more
europepmc +2 more sources
Contexto: A adolescência é uma etapa desenvolvimental com mudanças biológicas, psicológicas e sociais que irão influenciar o funcionamento na idade adulta.
Diogo Carreiras +2 more
doaj +1 more source
Objetivos: O objetivo do presente estudo foi testar o papel mediador do medo de receber compaixão dos outros e dos sentimentos de segurança e proximidade, em contexto social, na associação entre vergonha externa e o bem-estar psicológico dos adolescentes.
Ana Laura Mendes +2 more
doaj +1 more source

