Results 111 to 120 of about 401,067 (330)

The conceptual relevance of assessment measures in patients with mild/mild-moderate Alzheimer\u27s disease [PDF]

, 2018
Introduction: This study aims to evaluate the conceptual relevance of four measures of disease activity in patients with mild/mild-moderate Alzheimer\u27s disease (AD): (1) the Alzheimer\u27s Disease Assessment Scale–Cognitive Subscale; (2) the Alzheimer\
Al-Zubeidi, Tamara, Aldhouse, Natalie V.J., Hartry, Ann, Knight, Sarah L., Sanon, Myrlene, Stefanacci, Richard G.   +5 more
core   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Brain age and other bodily ‘ages’: implications for neuropsychiatry [PDF]

, 2018
James H. Cole, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary   +3 more
openalex   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Editorial: Social Interaction in Neuropsychiatry

Frontiers in Psychiatry, 2021
Victoria Leong, Victoria Leong, Danilo Bzdok, Danilo Bzdok, Frieder M. Paulus, Kevin Pelphrey, Elizabeth Redcay, Leonhard Schilbach   +7 more
doaj   +1 more source

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid

Advanced Science, EarlyView.
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Samuel Peña‐Díaz, Yanting Jiang, Zhefei Zhang, Anders Daugberg, Pedro Ferreira, Marcos López Hernández, Chandrika Mittal, Maria Joao Ramos, Jan Skov Pedersen, Morten Kam Dahl Dueholm, Cao Qin, Huabing Wang, Daniel E. Otzen   +12 more
wiley   +1 more source

Five linguistic misrepresentations of Huntington’s disease

Open Health
The efficacy of communication about medical research lies in the ability to relay medical jargon in scientific papers. When inaccurate terms are used in the medical literature, for example of diseases or conditions due to paraphrasing, then the impact of
Teixeira da Silva Jaime A.
doaj   +1 more source

Exploring telediagnostic procedures in child neuropsychiatry: addressing ADHD diagnosis and autism symptoms through supervised machine learning [PDF]

, 2022
Silvia Grazioli, Alessandro Crippa, Eleonora Rosi, Antonio Candelieri, Silvia Busti Ceccarelli, Maddalena Mauri, Martina Manzoni, Valentina Mauri, Sara Trabattoni, Massimo Molteni, Paola Colombo, Maria Nobile   +11 more
openalex   +1 more source

Research Progress on Idebenone in Neurodegenerative Diseases

AGING MEDICINE, EarlyView.
The study not only summarizes the biological properties of Idebenone (IDE), including its role in improving mitochondrial function and antioxidative stress, but also explores its clinical research progress in various neurodegenerative diseases, providing a new perspective for the treatment of these disorders.
Yanqing Zhang, Yanhong Ren, Xiaoran Zhu, Tianhao Liu, Rundong Han, Yuqing Fang, Zhangning Zhao, Fei Mao, Yalin Wang, Xian Li, Xiuhua Li   +10 more
wiley   +1 more source

Assessing in-vitro models for microglial development and fetal programming: a critical review

Frontiers in Immunology
This review evaluates in-vitro models for studying how maternal influences during pregnancy impact the development of offspring microglia, the immune cells of the central nervous system.
Steven Schepanski, Steven Schepanski, Gonza B. Ngoumou, Gonza B. Ngoumou, Claudia Buss, Claudia Buss, Claudia Buss, Claudia Buss, Georg Seifert, Georg Seifert   +9 more
doaj   +1 more source