Results 141 to 150 of about 399,854 (379)
Advanced Science, EarlyView.This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni +14 more
wiley +1 more source
Advanced Image‐Guidance and Surgical‐Navigation Techniques for Real‐Time Visualized Surgery
Advanced Science, EarlyView.This review comprehensively summarizes advances in surgical navigation, covering both established and emerging intraoperative imaging technologies. It highlights mechanisms, advantages, limitations, and clinical applications, while emphasizing interdisciplinary collaboration.
Xiaoxiao Fan +9 more
wiley +1 more source
The conceptual relevance of assessment measures in patients with mild/mild-moderate Alzheimer\u27s disease [PDF]
, 2018 Introduction: This study aims to evaluate the conceptual relevance of four measures of disease activity in patients with mild/mild-moderate Alzheimer\u27s disease (AD): (1) the Alzheimer\u27s Disease Assessment Scale–Cognitive Subscale; (2) the Alzheimer\
Al-Zubeidi, Tamara +5 more
core +1 more source
Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau. [PDF]
, 2020 In this study, we aimed to assess whether women are able to withstand more tau before exhibiting verbal memory impairment. Using data from 121 amyloid-β-positive Alzheimer's Disease Neuroimaging Initiative participants, we fit a linear model with Rey ...
Alzheimer’s Disease Neuroimaging Initiative +6 more
core
Dual Hydrophilic‐Hydrophobic Core Architecture in Soy Glycinin Amyloid Fibrils Revealed by Cryo‐EM
Advanced Science, EarlyView.While high‐resolution structures of animal and microbial amyloids are extensively characterized, the structural principles underlying plant‐derived amyloids remain largely unexplored. The study addresses this fundamental gap in knowledge by determining the first near‐atomic‐resolution cryo‐EM structures of amyloid fibrils derived from soy glycinin ...
Saiya Li +5 more
wiley +1 more source
Assessing in-vitro models for microglial development and fetal programming: a critical review
Frontiers in ImmunologyThis review evaluates in-vitro models for studying how maternal influences during pregnancy impact the development of offspring microglia, the immune cells of the central nervous system.
Steven Schepanski +9 more
doaj +1 more source
Parabiosis, Assembloids, Organoids (PAO)
Advanced Science, EarlyView.This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong +5 more
wiley +1 more source
Proceedings of the joint summer meeting of the British and American Neuropsychiatry Associations, 12-14 July 1992, Oxford. [PDF]
, 1992 openalex +1 more source
Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice
Advanced Science, EarlyView.Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao +12 more
wiley +1 more source