Results 121 to 130 of about 1,400,187 (379)

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells

iScience, 2019
Summary: We report that cerebrum-specific inactivation of the histone deacetylase 3 (HDAC3) gene causes striking developmental defects in the neocortex, hippocampus, and corpus callosum; post-weaning lethality; and abnormal behaviors, including ...
Lin Li, Jianliang Jin, Xiang-Jiao Yang
doaj  

Editorial Special Topic: Neuroscience, Learning, and Educational Practice—Challenges, Promises, and Applications

AERA Open, 2018
There is growing interest in the contributions of neuroscience to educational practice; however, to date, neuroscience seems to have had little impact on education.
Susanne M. Jaeggi, Priti Shah
doaj   +1 more source

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Theoretical Models of Neural Development

iScience, 2018
Constructing a functioning nervous system requires the precise orchestration of a vast array of mechanical, molecular, and neural-activity-dependent cues.
Geoffrey J. Goodhill
doaj  

Can Religiosity Be Explained by ‘Brain Wiring’? An Analysis of US Adults’ Opinions

Religions, 2019
Studies examining how religion shapes individuals’ attitudes about science have focused heavily on a narrow range of topics, such as evolution. This study expands this literature by looking at how religion influences individuals’ attitudes ...
Sharan Kaur Mehta, Christopher P. Scheitle, Elaine Howard Ecklund   +2 more
doaj   +1 more source

Definition of Cybernetical Neuroscience [PDF]

arXiv
A new scientific field is introduced and discussed, named cybernetical neuroscience, which studies mathematical models adopted in computational neuroscience by methods of cybernetics -- the science of control and communication in a living organism, machine and society.
arxiv  

Prediction and Topological Models in Neuroscience [PDF]

In the last two decades, philosophy of neuroscience has predominantly focused on explanation. Indeed, it has been argued that mechanistic models are the standards of explanatory success in neuroscience over, among other things, topological models ...
A Hofstadter, A Khazaee, A Khazaee, AM Jolly, BR Geib, BR Geib, C Hempel, C Klein, CF Craver, CF Craver, CF Craver, CF Craver, CF Craver, CG Hempel, CJ Stam, CJ Stam, CJ Stam, CT Butts, DE Woodhouse, DJ Watts, DM Kaplan, DS Bassett, DS Bassett, E Eells, E Nagel, E Sarigöl, EK Towlson, EW Dijkstra, F Liljeros, FP Battaglia, G Gong, GL Collingridge, H Douglas, H Longino, HE Douglas, I Scheffler, J Barrett, J delEtoile, J Wang, J Woodward, JB Colby, JJ Potterat, JL Wylie, K Popper, L Darden, L Deuker, M Lange, M Lange, M Newman, M Scriven, MD Sacchet, ML Stanley, MP van den Heuvel, MS Albert, NR Hanson, O Helmer, O Sporns, O Sporns, P Hagmann, P Huneman, P Kitcher, P Park, P Wang, PK Machamer, Q Gong, R Salvador, RB Rothenberg, RF Betzel, S Achard, S Achard, S Bromberger, S Glennan, S Micheloyannis, S Schindler, SF Muldoon, SH Hojjati, VM Eguíluz, W Bechtel, W Salmon, W Salmon, WC Salmon, X He, Y He, ZA Monge   +83 more
core   +1 more source

Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie, Manuela M. X. Tan, Maren Stolp Andersen, Mathias Toft, Lasse Pihlstrøm   +4 more
wiley   +1 more source

Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation

iScience, 2019
Summary: Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorders (ASDs) in human genetic studies. Here we found that chemogenetic activation of pyramidal neurons in the prefrontal cortex (PFC) of Shank3-deficient mice with ...
Luye Qin, Kaijie Ma, Zhen Yan
doaj