Results 21 to 30 of about 799,476 (293)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Correction: Neumeier et al. The Loneliness of Migraine Scale: A Development and Validation Study. Clin. Transl. Neurosci. 2022, 6, 12

Clinical and Translational Neuroscience
The Clinical and Translational Neuroscience Editorial Office would like to make the following correction to the Academic Editor listed on this published paper [...]
Clinical and Translational Neuroscience Editorial Office
doaj   +1 more source

Theoretical Models of Neural Development

iScience, 2018
Constructing a functioning nervous system requires the precise orchestration of a vast array of mechanical, molecular, and neural-activity-dependent cues.
Geoffrey J. Goodhill
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Menelusuri Jejak Otak dan ‘Aql Dalam Alquran Perspektif Neurosains dan Pendidikan Islam di Era Pandemi Covid-19

Tadris: Jurnal Pendidikan Islam, 2021
The purpose of this research analyzing Islamic education learning in the era of the Covid-19 pandemic from the perspective of Neuroscience. The development of the learning model of Islamic education and neuroscience in this modern era is in line with ...
Mohammad Jailani, Suyadi, Dedi Djubaedi
doaj   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Neuroscience Literacy and Academic Outcomes: Insights from a University Student Population

Brain Sciences
Background/Objectives: There is growing interest in neuroscience-informed education, as well as neuroscience-derived strategies that maximise learning.
Abeer F. Almarzouki, Arzan I. Alqahtani, Jumana K. Baessa, Dhuha K. Badaood, Rwdyn R. Nujoom, Raneem W. Malibari, Elaf M. Aljared, Reema S. Alghamdi   +7 more
doaj   +1 more source

Kajian Neuroscience dalam Pengembangan Ilmu Sekolah Dasar

Jurnal Inovasi Pendidikan dan Pembelajaran Sekolah Dasar, 2020
This article aims to explain the implementation of neuroscience studies in the development of science in elementary schools. The method of writing this article is literature study by exploring various scientific papers related to this topic.
Rizky Amelia, Kus Eddy Sartono, Chairil Faif Pasani   +2 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis

iScience, 2019
Summary: Learning to perceptually discriminate between chemical signals in the environment (olfactory perceptual learning [OPL]) is critical for survival.
Arielle Schilit Nitenson, Gabriela Manzano Nieves, Devon Lynn Poeta, Ryan Bahar, Carolyn Rachofsky, Nathalie Mandairon, Kevin G. Bath   +6 more
doaj   +1 more source