Results 41 to 50 of about 502,782 (269)

Does Psichoanalisis Concern for the Study of Cognition

open access: yesPsicologia, 2004
Since Freud, the body assumes a new configuration and sexuality opens up a promising theoretical field of inquiry into the brain. When combined with the theory of self organizing systems, the Freudian concept of drive becomes a useful conceptual tool in
Carla Laino Cândido
doaj  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

open access: yesFEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura   +19 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

Law and Neuroscience [PDF]

open access: yesThe Journal of Neuroscience, 2013
### Introduction Law and neuroscience seem strange bedfellows. But the engagement of law with neuroscientific evidence was inevitable. For one thing, the effectiveness of legal systems in regulating behavior and meting out justice often depends on weighing evidence about how and why a ...
Jones, Owen D   +3 more
openaire   +3 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Ensinar neurociências em educação física no Brasil: uma proposta de integração Enseñar neurociencia en educación física en Brasil: un propuesta de integración Teaching Neuroscience in Physical Education in Brazil: A Proposal for Integration

open access: yesEducación y Educadores, 2012
Ante a efetividade da neurociência no desenvolvimento de diferentes áreas do conhecimento, propõe-se adotar o ensino dessa disciplina nos programas de educação física, com o objetivo de que estudantes e profissionais aprendam estratégias didáticas que ...
André Luiz Monezi-Andrade   +3 more
doaj  

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi   +19 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano   +11 more
wiley   +1 more source

Opportunities and challenges for neurosurgeon in the brain research era

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2019
The neurosurgeons of PLA General Hospital are making effort to participate in the China Brain Project from the aspects of Science, Technology, Engineering and Medicine, namely "STEM".
Xin⁃guang YU, Yan⁃yang ZHANG
doaj  

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