Results 1 to 10 of about 22,400 (295)

Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain [PDF]

Frontiers in Aging Neuroscience
IntroductionNeurosphere culture is widely used to expand neural stem and progenitor cells (NSPCs) of the nervous system. Understanding the identity of NSPCs, such as the principals involved in spatiotemporal patterning, will improve our chances of using ...
Saeideh Aran, Mohammad Ghasem Golmohammadi, Mohsen Sagha, Kamran Ghaedi   +3 more
doaj   +2 more sources

DFMO inhibition of neuroblastoma tumorigenesis [PDF]

Cancer Medicine
Background Most high‐risk neuroblastoma patients who relapse succumb to disease despite the existing therapy. We recently reported increased event‐free and overall survival in neuroblastoma patients receiving difluoromethylornithine (DFMO) during ...
Divya Gandra, David H. Mulama, David M. Foureau, Kimberly Q. McKinney, Elizabeth Kim, Kaitlyn Smith, Jason Haw, Abhinav Nagulapally, Giselle L. Saulnier Sholler   +8 more
doaj   +2 more sources

Nuclear hormone receptors control fundamental processes of human fetal neurodevelopment: Basis for endocrine disruption assessment [PDF]

Environment International
Despite growing awareness of endocrine disrupting chemicals (EDCs), knowledge gaps remain regarding their effects on human brain development. EDC risk assessment focuses primarily on EATS modalities (estrogens, androgens, thyroid hormones, and ...
Katharina Koch, Kevin Schlüppmann, Saskia Hüsken, Louisa Merit Stark, Nils Förster, Stefan Masjosthusmann, Jördis Klose, Arif Dönmez, Ellen Fritsche   +8 more
doaj   +2 more sources

Human Patient-Derived Brain Tumor Models to Recapitulate Ependymoma Tumor Vasculature

Bioengineering, 2023
Despite in vivo malignancy, ependymoma lacks cell culture models, thus limiting therapy development. Here, we used a tunable three-dimensional (3D) culture system to approximate the ependymoma microenvironment for recapitulating a patient’s tumor in ...
Min D. Tang-Schomer, Markus J. Bookland, Jack E. Sargent, Taylor N. Jackvony   +3 more
doaj   +1 more source

Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells

Frontiers in Cell and Developmental Biology, 2022
Genomic imprinting is an epigenetic process through which genes are expressed in a parent-of-origin specific manner resulting in mono-allelic or strongly biased expression of one allele.
Michael Claxton, Michael Claxton, Michela Pulix, Michelle K. Y. Seah, Ralph Bernardo, Peng Zhou, Sultan Aljuraysi, Sultan Aljuraysi, Triantafillos Liloglou, Philippe Arnaud, Gavin Kelsey, Gavin Kelsey, Gavin Kelsey, Daniel M. Messerschmidt, Daniel M. Messerschmidt, Antonius Plagge   +15 more
doaj   +1 more source

Differential Susceptibility of Ex Vivo Primary Glioblastoma Tumors to Oncolytic Effect of Modified Zika Virus

Cells, 2023
Glioblastoma (GBM), the most common primary malignant brain tumor, is a highly lethal form of cancer with a very limited set of treatment options. High heterogeneity in the tumor cell population and the invasive nature of these cells decrease the likely ...
Gustavo Garcia, Nikhil Chakravarty, Sophia Paiola, Estrella Urena, Priya Gyani, Christopher Tse, Samuel W. French, Moise Danielpour, Joshua J. Breunig, David A. Nathanson, Vaithilingaraja Arumugaswami   +10 more
doaj   +1 more source

The Neural Multilineage Differentiation Capacity of Human Neural Precursors from the Umbilical Cord—Ready to Bench for Clinical Trials

Membranes, 2022
Mesenchymal stem cells (MSC) are promising for regenerative medicine as they have a vast differentiation capacity, immunomodulatory properties and can be isolated from different tissues.
Daiany de Souza Dobuchak, Priscila Elias Ferreira Stricker, Nathalia Barth de Oliveira, Bassam Felipe Mogharbel, Nádia Nascimento da Rosa, Dilcele Silva Moreira Dziedzic, Ana Carolina Irioda, Katherine Athayde Teixeira de Carvalho   +7 more
doaj   +1 more source

Isolating Globose Basal Stem Cells from Albino Wistar Rats Using a Highly Specific Monoclonal Antibody [PDF]

Journal of Clinical and Diagnostic Research, 2013
Introduction: Olfactory mucosa which is situated in the roof of the nasal cavity possesses an extremely peculiar and exceptional type of pluripotent stem cells called Globose Basal Cells (GBCs) which help in lifelong regeneration of the olfactory ...
Avinash Thakur, Duraimurugan Muniswami, George Tharion, Indirani Kanakasabapathy   +3 more
doaj   +1 more source

Differential contribution of TrkB and p75NTR to BDNF-dependent self-renewal, proliferation, and differentiation of adult neural stem cells

Frontiers in Molecular Neuroscience, 2023
Alterations in adult neurogenesis are a common hallmark of neurodegenerative diseases. Therefore, understanding the molecular mechanisms that control this process is an indispensable requirement for designing therapeutic interventions addressing ...
Anna Lozano-Ureña, José M. Frade
doaj   +1 more source

Generation of Porcine Induced Neural Stem Cells Using the Sendai Virus

Frontiers in Veterinary Science, 2022
The reprogramming of cells into induced neural stem cells (iNSCs), which are faster and safer to generate than induced pluripotent stem cells, holds tremendous promise for fundamental and frontier research, as well as personalized cell-based therapies ...
Warunya Chakritbudsabong, Warunya Chakritbudsabong, Ladawan Sariya, Phakhin Jantahiran, Phakhin Jantahiran, Nattarun Chaisilp, Somjit Chaiwattanarungruengpaisan, Ruttachuk Rungsiwiwut, Joao N. Ferreira, Joao N. Ferreira, Sasitorn Rungarunlert, Sasitorn Rungarunlert   +11 more
doaj   +1 more source