Results 1 to 10 of about 17,973 (254)
Cecal growth factors promote enteric neurosphere formation and hindgut colonization in the avian model [PDF]
Frontiers in Cell and Developmental BiologyIntroductionThe enteric nervous system (ENS) originates from neural crest cells (NCC) that migrate along the developing gut and differentiate into enteric neurons and glial cells.
Ádám Soós +9 more
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Isolation and Culture of Neurospheres for the Study of Pathogenesis of Prion Disease [PDF]
Bio-Protocol, 2014 Neurosphere contains neural stem cells that are capable of self-renewal and multilineage differentiation including neurons, astrocytes, and oligodendrocytes (Gage, 2000).
Yoshi Iwamaru +2 more
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Inhibition of Neurosphere Formation in Neural Stem/Progenitor Cells by Acrylamide
Cell Transplantation, 2015 Previous studies showed that transplantation of cultured neural stem/progenitor cells (NSPCs) could improve functional recovery for various neurological diseases. This study aims to develop a stem cell-based model for predictive toxicology of development
Jong-Hang Chen +4 more
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Bio-Protocol, 2016 The hippocampal niche is one of two areas in the brain where stem cells reside. In this neurogenic niche, stem cells can be found in close proximity to astrocytes and in contact with microvessels consisting of pericytes and endothelial cells.
Fanny Ehret +2 more
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Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation [PDF]
Frontiers in Toxicology, 2022 There is a call for a paradigm shift in developmental neurotoxicity (DNT) evaluation, which demands the implementation of faster, more cost-efficient, and human-relevant test systems than current in vivo guideline studies.
Katharina Koch +10 more
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Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation [PDF]
Stem Cells International, 2015 Neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) are traditionally maintained and proliferated utilizing two‐dimensional (2D) adherent monolayer culture systems. However, NPCs cultured using this system hardly reflect the intrinsic spatial development of brain tissue.
Shuling Zhou +12 more
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Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain [PDF]
Frontiers in Aging NeuroscienceIntroductionNeurosphere culture is widely used to expand neural stem and progenitor cells (NSPCs) of the nervous system. Understanding the identity of NSPCs, such as the principals involved in spatiotemporal patterning, will improve our chances of using ...
Saeideh Aran +3 more
doaj +2 more sources
Human Patient-Derived Brain Tumor Models to Recapitulate Ependymoma Tumor Vasculature
Bioengineering, 2023 Despite in vivo malignancy, ependymoma lacks cell culture models, thus limiting therapy development. Here, we used a tunable three-dimensional (3D) culture system to approximate the ependymoma microenvironment for recapitulating a patient’s tumor in ...
Min D. Tang-Schomer +3 more
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Generation of Porcine Induced Neural Stem Cells Using the Sendai Virus
Frontiers in Veterinary Science, 2022 The reprogramming of cells into induced neural stem cells (iNSCs), which are faster and safer to generate than induced pluripotent stem cells, holds tremendous promise for fundamental and frontier research, as well as personalized cell-based therapies ...
Warunya Chakritbudsabong +11 more
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Prion infection of mouse neurospheres [PDF]
Proceedings of the National Academy of Sciences, 2006 Only a few cell lines have been infected with prions, offering limited genetic diversity and sensitivity to several strains. Here we report that cultured neurospheres expressing cellular prion protein (PrP C ) can be infected with prions. Neurosphere lines isolated from the brains of mice at embryonic day 13–15 grow
Ranjit K, Giri +5 more
openaire +2 more sources