Results 101 to 110 of about 22,415 (298)
Frontiers in Aging Neuroscience, 2017 Impairment of hippocampal adult neurogenesis in aging or degenerating brain is a well-known phenomenon caused by the shortage of brain stem cell pool, alterations in the local microenvironment within the neurogenic niches, or deregulation of stem cell ...
Vladimir V. Salmin +15 more
doaj +1 more source
Advanced Science, EarlyView.Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang +21 more
wiley +1 more source
Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells [PDF]
, 2004 Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. NSCs can be directly isolated from fetal or adult nervous tissue,
Boehm, Bernhard O. +10 more
core
Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3. [PDF]
PLoS ONE, 2017 The growth factor and cytokine regulated transcription factor STAT3 is required for the self-renewal of several stem cell types including tumor stem cells from glioblastoma.
Maureen M Sherry-Lynes +3 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai +7 more
wiley +1 more source
Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation
Stem Cells International, 2015 Neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) are traditionally maintained and proliferated utilizing two-dimensional (2D) adherent monolayer culture systems.
Shuling Zhou +12 more
semanticscholar +1 more source
Differentiation of neurosphere after transplantation into the damaged spinal cord
Journal of Medicine and Life, 2023 This study aimed to compare the differentiation and survival of human neural stem/progenitor cells of various origins in vitro and after transplantation into the injured spinal cord of laboratory animals. Rats with simulated spinal cord injury were transplanted with neurosphere cells obtained by directed differentiation of HUES6 cell lines ...
Gramatiuk, Svetlana Mykolaiivna +5 more
openaire +2 more sources
The transcriptional coactivator Querkopf controls adult neurogenesis [PDF]
, 2006 The adult mammalian brain maintains populations of neural stem cells within discrete proliferative zones. Understanding of the molecular mechanisms regulating adult neural stem cell function is limited.
Bartlett, P. F. +6 more
core +2 more sources
Annals of Neurology, EarlyView.This study demonstrates that intranasal Wharton's jelly‐derived mesenchymal stem cell (WJ‐MSC) administration at 3 or 10 days post‐insult reduced the lesion size and sensorimotor impairment following neonatal hypoxic‐ischemic (HI) brain injury in mice. WJ‐MSCs expressed receptors for HI‐upregulated chemokines and migrated from the nasal cavity into the
Caroline G. M. de Theije +9 more
wiley +1 more source
DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. [PDF]
, 2017 INTRODUCTION:The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways.
Chidambaran, Vidya +8 more
core +1 more source