Results 121 to 130 of about 22,415 (298)

Long-lasting anxiolytic effect of neural precursor cells freshly prepared but not neurosphere-derived cell transplantation in newborn rats [PDF]

, 2014
Background: the GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into GABAergic interneurons and modify
Barnabe, Gabriela Filoso, Calcagnotto, Maria Elisa, Frussa-Filho, Roberto, Longo, Beatriz Monteiro, Paiva, Daisylea de Souza, Romariz, Simone Amaro Alves, Silva, Regina Claudia Barbosa da, Valente, Maria Fernanda   +7 more
core   +4 more sources

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment

Epilepsia, EarlyView.
Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones, Silvia Lindlar, Johannes Ludwig, Regina Waltes, Afsheen Kumar, Sophie v. Brauchitsch, Andrea Rossi, Evelyn Ullrich, Stefan Momma, Christine M. Freitag, Jasmin K. Hefendehl, Karl Martin Klein, Felix Rosenow, Denise Haslinger, Andreas G. Chiocchetti   +14 more
wiley   +1 more source

Integrin targeted photodynamic therapy in patient‐derived glioblastoma spheroids

Photochemistry and Photobiology, EarlyView.
A novel targeted photodynamic therapy (PDT) agent, SiPc‐2c(RGDfK), was used to treat patient‐derived glioma stem cell spheroids expressing varying levels of the V3 integrin. The quantitative measurement of cytotoxicity following treatment demonstrated the therapeutic efficacy of SiPc‐2c(RGDfK) on V3‐expressing single spheroids, effectively ...
Miriam Roberto, Meedie Ali, Ivo Que, Rachele Stefania, Henriette S. de Bruijn, Dominic J. Robinson, Francesco Blasi, Luca D. D'Andrea, Enzo Terreno, Laura Mezzanotte   +9 more
wiley   +1 more source

In Vivo Transplantation of Neurosphere-Like Bodies Derived from the Human Postnatal and Adult Enteric Nervous System: A Pilot Study

PLoS ONE, 2014
Recent advances in the in vitro characterization of human adult enteric neural progenitor cells have opened new possibilities for cell-based therapies in gastrointestinal motility disorders. However, whether these cells are able to integrate within an in
S. Hetz, A. Acikgoez, U. Voss, K. Nieber, H. Holland, C. Hegewald, H. Till, R. Metzger, M. Metzger   +8 more
semanticscholar   +1 more source

A novel three-dimensional system to study interactions between endothelial cells and neural cells of the developing central nervous system [PDF]

, 2011
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Milner, Richard
core   +2 more sources

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Latent stem and progenitor cells in the hippocampus are activated by neural excitation [PDF]

, 2008
The regulated production of neurons in the hippocampus throughout life underpins important brain functions such as learning and memory. Surprisingly, however, studies have so far failed to identify a resident hippocampal stem cell capable of providing ...
Bartlett, Perry F., Black, Debra M., Sah, Pankaj, Walker, Tara L., Wallace, Robyn H., White, Amanda   +5 more
core   +1 more source

Astrocytes influence medulloblastoma phenotypes and CD133 surface expression.

PLoS ONE, 2020
The medulloblastoma (MB) microenvironment is diverse, and cell-cell interactions within this milieu is of prime importance. Astrocytes, a major component of the microenvironment, have been shown to impact primary tumor cell phenotypes and metastasis ...
Emily Gronseth, Ankan Gupta, Chris Koceja, Suresh Kumar, Raman G Kutty, Kevin Rarick, Ling Wang, Ramani Ramchandran   +7 more
doaj   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, Volume 15, Issue 9, Page 1436-1458, September 2025.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Using Primary Neurosphere Cultures to Study Primary Cilia

Journal of Visualized Experiments, 2017
The primary cilium is fundamentally important for the proliferation of neural stem/progenitor cells and for neuronal differentiation during embryonic, postnatal, and adult life. In addition, most differentiated neurons possess primary cilia that house signaling receptors, such as G-protein-coupled receptors, and signaling molecules, such as adenylyl ...
Hemant B. Badgandi, Saikat Mukhopadhyay, Issei S. Shimada, Bandarigoda N. Somatilaka   +3 more
openaire   +3 more sources