In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review
Abstract Valproic acid (VPA) is a first‐line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal valproate spectrum disorder (FVSD), which may include neurocognitive and neurobehavioral deficits, the drug
Daniel Sandvik+5 more
wiley +1 more source
Using Primary Neurosphere Cultures to Study Primary Cilia
The primary cilium is fundamentally important for the proliferation of neural stem/progenitor cells and for neuronal differentiation during embryonic, postnatal, and adult life. In addition, most differentiated neurons possess primary cilia that house signaling receptors, such as G-protein-coupled receptors, and signaling molecules, such as adenylyl ...
Hemant B. Badgandi+3 more
openaire +3 more sources
Astrocytes influence medulloblastoma phenotypes and CD133 surface expression.
The medulloblastoma (MB) microenvironment is diverse, and cell-cell interactions within this milieu is of prime importance. Astrocytes, a major component of the microenvironment, have been shown to impact primary tumor cell phenotypes and metastasis ...
Emily Gronseth+7 more
doaj +1 more source
Integrin targeted photodynamic therapy in patient‐derived glioblastoma spheroids
A novel targeted photodynamic therapy (PDT) agent, SiPc‐2c(RGDfK), was used to treat patient‐derived glioma stem cell spheroids expressing varying levels of the V3 integrin. The quantitative measurement of cytotoxicity following treatment demonstrated the therapeutic efficacy of SiPc‐2c(RGDfK) on V3‐expressing single spheroids, effectively ...
Miriam Roberto+9 more
wiley +1 more source
An efficient method for the transduction of primary pediatric glioma neurospheres
Pediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are rare, but rapidly fatal malignancies of the central nervous system (CNS), and the leading cause of cancer-related death in children. Besides the scarcity of available biological material for research, the study of these diseases has been hampered by methodological ...
Michaël H. Meel+4 more
openaire +4 more sources
Early adversity and the comorbidity between metabolic disease and psychopathology
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas+1 more
wiley +1 more source
A novel fluorescent reporter CDy1 enriches for neural stem cells derived from the murine brain [PDF]
Neurogenesis occurs continuously in two brain regions of adult mammals, underpinned by a pool of resident neural stem cells (NSCs) that can differentiate into all neural cell types.
Bartlett, Perry F.+3 more
core +1 more source
Increased production, oligomerization and aggregation of amyloid-β (Aβ) peptides are hallmark pathologies of Alzheimer’s disease (AD). Expressing familial AD mutations (amyloid precursor protein and/or presenilins mutations), the Aβ-pathologies of AD has
P. S. Ghate+3 more
semanticscholar +1 more source
HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim+9 more
wiley +1 more source
The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells [PDF]
Doublecortin (DCX) has recently been promulgated as a selective marker of cells committed to the neuronal lineage in both the developing and the adult brain.
Adams, D. J.+3 more
core +1 more source