Results 131 to 140 of about 22,415 (298)
The Atypical Cell Cycle Regulator Spy1 Suppresses Differentiation of the Neuroblastoma Stem Cell Population [PDF]
, 2014 Neuroblastoma is an aggressive pediatric cancer originating embryonically from the neural crest. The heterogeneity of the disease, as most solid tumors, complicates diagnosis and treatment.
Lubanska, Dorota, Porter, Lisa A.
core +3 more sources
Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection
BioEssays, Volume 47, Issue 9, September 2025.Embryonic radial glia (RG) generate neurons, glial cells, and later adult neural stem cells, which sustain adult neurogenesis (top, left to right). Human‐specific genetic modifications (blue arrow), selected to boost early RG neurogenic activity, may lead to premature RG exhaustion and reduced adult neurogenesis in the human brain (bottom).
David Morizet, Laure Bally‐Cuif
wiley +1 more source
p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells [PDF]
, 2007 Although our understanding of adult neurogenesis has increased dramatically over the last decade, confusion still exists regarding both the identity of the stem cell responsible for neuron production and the mechanisms that regulate its activity. Here we
Bartlett, P. F. +4 more
core +1 more source
What Does Iron Mean to an Oligodendrocyte?
Glia, Volume 73, Issue 9, Page 1784-1804, September 2025.Main Points Iron is essential for oligodendrocyte (OL) biology and myelin production, with deficiencies leading to severe neurological impairments. Understanding iron trafficking in OLs is crucial for developing treatments for dysmyelinating conditions. ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions.
Quinn W. Wade, James R. Connor
wiley +1 more source
Generation of Oligodendrocyte Progenitor Cells From Mouse Bone Marrow Cells. [PDF]
, 2019 Oligodendrocyte progenitor cells (OPCs) are a subtype of glial cells responsible for myelin regeneration. Oligodendrocytes (OLGs) originate from OPCs and are the myelinating cells in the central nervous system (CNS).
Casella, Giacomo +9 more
core +1 more source
Decoding Pain: Next‐Generation In Vitro Systems for Mechanistic Insights and Drug Discovery
The FASEB Journal, Volume 39, Issue 16, 31 August 2025.Developing an in vitro pain model that mimics essential features of the in vivo pain circuit requires careful consideration of multiple components and choices. These include selecting the cellular population for the model, choosing from the origin of nociceptors and other cells that are cultured, deciding between 3D or 2D dimensions, designing the ...
Dara Khosrowshahi +2 more
wiley +1 more source
SpringerPlus, 2014 Increased production, oligomerization and aggregation of amyloid-β (Aβ) peptides are hallmark pathologies of Alzheimer’s disease (AD). Expressing familial AD mutations (amyloid precursor protein and/or presenilins mutations), the Aβ-pathologies of AD has
P. S. Ghate +3 more
semanticscholar +1 more source
Perlecan is required for FGF-2 signaling in the neural stem cell niche
Stem Cell Research, 2014 In the adult subventricular zone (neurogenic niche), neural stem cells double-positive for two markers of subsets of neural stem cells in the adult central nervous system, glial fibrillary acidic protein and CD133, lie in proximity to fractones and to ...
Aurelien Kerever +9 more
doaj +1 more source
The FASEB Journal, Volume 39, Issue 16, 31 August 2025.Human induced pluripotent stem cells were differentiated into neural stem cells and floor plate progenitors of dopaminergic neurons, followed by microRNA profiling. While intracellular differences were limited, extracellular vesicle microRNAs showed 27 differentially expressed microRNAs and five consistently enriched across lineages.
Lilian Cruz +10 more
wiley +1 more source
Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/β-Catenin Pathway by Its GAP Domain [PDF]
, 2016 Neural stem cell (NSC) proliferation and differentiation play a pivotal role in the development of brain, the plasticity of the brain network and the repair for brain function in CNS diseases.
Dongfu eFeng +10 more
core +2 more sources