Results 141 to 150 of about 22,400 (295)
Journal of Toxicological Sciences, 2014 Exposure to environmental neurotoxic chemicals both in utero and during the early postnatal period can cause neurodevelopmental disorders. To evaluate the disruption of neurodevelopmental programming, we previously established an in vitro neurosphere ...
M. Ishido, J. Suzuki
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CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.PRPF40B promotes circMAN1A2 expression, inhibiting TEP1‐KEAP1 complex formation, leading to NRF2 degradation and ferroptosis in GSCs. Without circMAN1A2, NRF2 activation inhibits ferroptosis and promotes TAMs' M2 polarization. ABSTRACT Background Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis and resistance to temozolomide ...
Xinqiao Li +7 more
wiley +1 more source
A novel three-dimensional system to study interactions between endothelial cells and neural cells of the developing central nervous system [PDF]
, 2011 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Milner, Richard
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Perlecan is required for FGF-2 signaling in the neural stem cell niche
Stem Cell Research, 2014 In the adult subventricular zone (neurogenic niche), neural stem cells double-positive for two markers of subsets of neural stem cells in the adult central nervous system, glial fibrillary acidic protein and CD133, lie in proximity to fractones and to ...
Aurelien Kerever +9 more
doaj +1 more source
Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro [PDF]
, 2001 Peer ...
Bismuth, Karen +7 more
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Norepinephrine directly activates adult hippocampal precursors via beta(3)-adrenergic receptors [PDF]
, 2010 Adult hippocampal neurogenesis is a critical form of cellular plasticity that is greatly influenced by neural activity. Among the neurotransmitters that are widely implicated in regulating this process are serotonin and norepinephrine, levels of which ...
Bartlett, Perry F. +6 more
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Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype [PDF]
, 2016 Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis.
Alfonsi, Romina +13 more
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In Vitro Cellular & Developmental Biology - Animal, 2014 Stem cell-based therapy holds great potential especially for neurological disorders. However, clinical applications await further understanding of many aspects of stem cell differentiation and development of technology enabling manipulation of stem cells
Kyuhee Park, Yeonju Nam, Yongmun Choi
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The adult mouse hippocampal progenitor is neurogenic but not a stem cell [PDF]
, 2005 The aim of this investigation was to characterize the proliferative precursor cells in the adult mouse hippocampal region. Given that a very large number of new hippocampal cells are generated over the lifetime of an animal, it is predicted that a neural
Bartlett, P. F., Bull, N. D.
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PLoS ONE, 2013 Mood stabilising drugs such as lithium (LiCl) and valproic acid (VPA) are the first line agents for treating conditions such as Bipolar disorder and Epilepsy. However, these drugs have potential developmental effects that are not fully understood.
E. Hill +6 more
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