Results 11 to 20 of about 17,973 (254)

Effects of FGF-2 and EGF removal on the differentiationof mouse neural precursor cells [PDF]

Anais da Academia Brasileira de Ciências, 2009
Cell therapy for neurological disorders has advanced, and neural precursor cells (NPC) may become the ideal candidates for neural transplantation in a wide range of diseases.
Telma T. Schwindt, Fabiana L. Motta, Barnabé Gabriela F., Massant Cristina G., Alessander O. Guimarães, Maria Elisa Calcagnotto, João B. Pesquero, Luiz E. Mello   +7 more
doaj   +4 more sources

Prolactin stimulates precursor cells in the adult mouse hippocampus. [PDF]

PLoS ONE, 2012
In the search for ways to combat degenerative neurological disorders, neurogenesis-stimulating factors are proving to be a promising area of research. In this study, we show that the hormonal factor prolactin (PRL) can activate a pool of latent precursor
Tara L Walker, Jana Vukovic, Margaretha M Koudijs, Daniel G Blackmore, Eirinn W Mackay, Alex M Sykes, Rupert W Overall, Adam S Hamlin, Perry F Bartlett   +8 more
doaj   +5 more sources

mRNA transfection of mouse and human neural stem cell cultures. [PDF]

PLoS ONE, 2013
The use of synthetic mRNA as an alternative gene delivery vector to traditional DNA-based constructs provides an effective method for inducing transient gene expression in cell cultures without genetic modification.
Samuel McLenachan, Dan Zhang, Ana Belén Alvarez Palomo, Michael J Edel, Fred K Chen   +4 more
doaj   +5 more sources

Engineering a Perfusion Bioreactor System for hiPSC-Derived Progenitor Co-Culture Capturing Microglial Features in CNS Development. [PDF]

Biotechnol Bioeng
The authors report the development of a controlled and scalable 3D co‐culture system combining hiPSC‐derived erythromyeloid progenitors and neurospheres within the Ambr® 250 Modular platform operated with a newly designed perfusion system. This model faithfully recapitulates early microglia–neural interactions, enabling progenitor integration ...
Gomes CM, de Sá I, Delgado M, Alves PM, Brito C.   +4 more
europepmc   +2 more sources

Enteric Neurospheres Are Not Specific to Neural Crest Cultures: Implications for Neural Stem Cell Therapies [PDF]

, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
A Barlow, A Pini Prato, A Zani, AG Baynash, AG Catto-Smith, AJ Burns, AJ Burns, Alan J. Burns, AS Wallace, C Caldwell, C Kalcheim, C Laranjeira, CH Knowles, Conor McCann, D Natarajan, Dipa Natarajan, DM Rodrigues, E Panza, Ellen Binder, GE Boeckxstaens, H Tsuji, HM Pallari, J Amiel, Jean-Marie Delalande, Julie Cooper, L Becker, L Ludman, M Hanani, M Metzger, Mara Cananzi, MC Nunes, MD Gershon, Mirella Dottori, MP Sanchez, MT Liu, N Bondurand, N Nagoshi, N Thapar, Nikhil Thapar, NR Druckenbrod, PS Danielian, R Hotta, R Hotta, R Zufferey, Rania Kronfli, RC Mifflin, RM Lindley, S Almond, S Bixby, S Hetz, S Srinivas, S Theocharatos, SJ Conway, SJ Howe, SJ McKeown, TA Heanue, TP Rothman, U Rauch, V Sasselli, X Jiang, Y Matsuda, YH Tsai   +61 more
core   +21 more sources

Subventricular Zone-on-a-Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage. [PDF]

Adv Sci (Weinh)
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Zamproni LN, Gökçe B, Gram M, Holliday C, Sendemir A, Porcionatto MA, Herland A.   +6 more
europepmc   +2 more sources

Establishment and Characterization of Brain Cancer Primary Cell Cultures From Patients to Enable Phenotypic Screening for New Drugs

Frontiers in Pharmacology, 2022
Aim: Desmoplastic infantile ganglioglioma (DIG), is a rare tumor arising mainly during the first 2 years of life. Molecular characterization of these benign yet rapidly proliferating tumors has been limited to evaluating a few mutations in few genes. Our
Michelle dePadua, Preethi Kulothungan, Rahul Lath, Ravikanti Prasad, Kranthi Madamchetty, Shravya Atmakuri, Sravanthi Ragamouni, Mukesh Gandhari, Lakshmipathi Khandrika, Jugnu Jain, Jugnu Jain   +10 more
doaj   +1 more source

Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb [PDF]

, 2007
Wedetermined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ...
Fogarty, M, Kessaris, N, Richardson, WD, Young, KM   +3 more
core   +4 more sources

The Neural Multilineage Differentiation Capacity of Human Neural Precursors from the Umbilical Cord—Ready to Bench for Clinical Trials

Membranes, 2022
Mesenchymal stem cells (MSC) are promising for regenerative medicine as they have a vast differentiation capacity, immunomodulatory properties and can be isolated from different tissues.
Daiany de Souza Dobuchak, Priscila Elias Ferreira Stricker, Nathalia Barth de Oliveira, Bassam Felipe Mogharbel, Nádia Nascimento da Rosa, Dilcele Silva Moreira Dziedzic, Ana Carolina Irioda, Katherine Athayde Teixeira de Carvalho   +7 more
doaj   +1 more source

Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells

Frontiers in Cell and Developmental Biology, 2022
Genomic imprinting is an epigenetic process through which genes are expressed in a parent-of-origin specific manner resulting in mono-allelic or strongly biased expression of one allele.
Michael Claxton, Michael Claxton, Michela Pulix, Michelle K. Y. Seah, Ralph Bernardo, Peng Zhou, Sultan Aljuraysi, Sultan Aljuraysi, Triantafillos Liloglou, Philippe Arnaud, Gavin Kelsey, Gavin Kelsey, Gavin Kelsey, Daniel M. Messerschmidt, Daniel M. Messerschmidt, Antonius Plagge   +15 more
doaj   +1 more source