Objectives Human dental pulp stem cells (DPSCs) have been used to regenerate damaged nervous tissues. However, the methods of committing DPSCs into neural stem/progenitor cells (NSPCs) or neurospheres are highly diverse, resulting in many neuronal ...
Thanasup GONMANEE+4 more
doaj +2 more sources
Characterisation of human gingival neural crest-derived stem cells in monolayer and neurosphere cultures [PDF]
Neural crest (NC)-derived stem cells (NCSC) have an exceptionally wide differentiation potential, but their use in regenerative therapy has been hampered by their scarcity in adult tissues and complex isolation protocols.
BP Fournier+5 more
doaj +2 more sources
The hippocampal niche is one of two areas in the brain where stem cells reside. In this neurogenic niche, stem cells can be found in close proximity to astrocytes and in contact with microvessels consisting of pericytes and endothelial cells.
Fanny Ehret+2 more
doaj +3 more sources
Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation
There is a call for a paradigm shift in developmental neurotoxicity (DNT) evaluation, which demands the implementation of faster, more cost-efficient, and human-relevant test systems than current in vivo guideline studies.
Katharina Koch+10 more
doaj +2 more sources
Effects of FGF-2 and EGF removal on the differentiationof mouse neural precursor cells [PDF]
Cell therapy for neurological disorders has advanced, and neural precursor cells (NPC) may become the ideal candidates for neural transplantation in a wide range of diseases.
Telma T. Schwindt+7 more
doaj +4 more sources
Developmental neurotoxic effects of Malathion on 3D neurosphere system
Developmental neurotoxicity (DNT) refers to the toxic effects induced by various chemicals on brain during the early childhood period. As human brains are vulnerable during this period, various chemicals would have significant effects on brains during early childhood.
Mohamed Salama+9 more
semanticscholar +5 more sources
Testosterone-induced adult neurosphere growth is mediated by sexually-dimorphic aromatase expression
We derived adult neural stem/progenitor cells (NSPCs) from the sub-ventricular zone of male and female mice to examine direct responses to principal sex hormones.
Mark Ian Ransome+2 more
doaj +2 more sources
mRNA transfection of mouse and human neural stem cell cultures. [PDF]
The use of synthetic mRNA as an alternative gene delivery vector to traditional DNA-based constructs provides an effective method for inducing transient gene expression in cell cultures without genetic modification.
Samuel McLenachan+4 more
doaj +5 more sources
Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells [PDF]
The postnatal subventricular zone lining the walls of the lateral ventricles contains neural progenitor cells (NPCs) that generate new olfactory bulb interneurons.
Rocío eTalaverón+5 more
doaj +3 more sources
Inhibition of Neurosphere Formation in Neural Stem/Progenitor Cells by Acrylamide
Previous studies showed that transplantation of cultured neural stem/progenitor cells (NSPCs) could improve functional recovery for various neurological diseases. This study aims to develop a stem cell-based model for predictive toxicology of development
Jong-Hang Chen+4 more
doaj +2 more sources