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Sprouty in Tumors of the Nervous System. [PDF]
Int J Mol SciObexer P, Hausott B.
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Imaging-guided platform for real-time intervention in complex in vitro models
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The mechanical properties of neurospheres
Advanced Engineering Materials, 2021Stem cell-derived 3D tissues such as spheroids are excellent models for investigating mechanisms of tissue formation and responses to physiological and mechanical cues. Neuronal spheroids, also known as neurospheres, have attracted particular interest.
Chike K. Okwara +5 more
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Genome-wide pooled CRISPR screening in neurospheres
Nature Protocols, 2023Spheroid culture systems have allowed in vitro propagation of cells unable to grow in canonical cell culturing conditions, and may capture cellular contexts that model tumor growth better than current model systems. The insights gleaned from genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screening of thousands of cancer ...
Tanaz Abid +12 more
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Neurosphere and neurosphere-forming cells: morphological and ultrastructural characterization
Brain Research, 2003Despite recent advances in our understanding of neural stem cell (NSC) biology, the free-floating structures generated by these cells in vitro, the "neurospheres", have not been fully characterized. To fill this gap, we examined neurospheres and neurosphere-derived NSCs by confocal microscopy, electron microscopy (EM) and cytofluorimetry. Here, we show
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The neurosphere assay, a method under scrutiny
Acta Neuropsychiatrica, 2008Objectives:The aim of this review is to provide an overview of the fundamental features of the neurosphere assay (NSA), which was initially described in 1992, and has since been used not only to detect the presence of stem cells in embryonic and adult mammalian neural tissues, but also to study their characteristicsin vitro.
Deleyrolle, Loic P. +2 more
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Retinal neurospheres prepared as tissue for transplantation
Developmental Brain Research, 2005The present work was conducted to study the cellular composition and developmental capacity of retinal neurospheres. Furthermore, the ability of grafted neurospheres to integrate into adult retinal tissue was studied in an in vitro model. Retinal progenitor cells isolated from rat embryos were expanded into neurospheres in vitro in the presence of ...
Ingela, Liljekvist-Larsson +1 more
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Extracellular matrix effects on neurosphere cell motility
Experimental Neurology, 2003There is a paucity of information on the roles of extracellular matrix (ECM) and substrate molecules in general with regard to the growth and differentiation of neural stem and progenitor cells. There are well-established findings of a dense, presumably astrocyte-derived ECM in the persistently neurogenic subependymal zone and its migratory extension ...
S M, Kearns +3 more
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Neurosphere segmentation in brightfield images
SPIE Proceedings, 2014The challenge of segmenting neurospheres (NSPs) from brightfield images includes uneven background illumination (vignetting), low contrast and shadow-casting appearance near the well wall. We propose a pipeline for neurosphere segmentation in brightfield images, focusing on shadow-casting removal.
Jierong Cheng +5 more
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