Results 251 to 260 of about 22,400 (295)

Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. [PDF]

PLoS One
Berezovsky A, Nuga O, Datta I, Bergman K, Sabedot T, Gurdziel K, Irtenkauf S, Hasselbach L, Meng Y, Mueller C, Petricoin EF, Brown S, Purandare N, Aras S, Mikkelsen T, Poisson L, Noushmehr H, Ruden D, deCarvalho AC.   +18 more
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Imaging of neurosphere oxygenation with phosphorescent probes.

Biomaterials, 2013
Multicellular spheroids are useful models of mammalian tissue for studies of cell proliferation, differentiation, replacement therapies and drug action. Having a size of 100-500 μm they mimic in vivo micro-environment and characteristic gradients of O2, pH and nutrients.
R. Dmitriev, Alexander V. Zhdanov, Y. Nolan, D. Papkovsky   +3 more
semanticscholar   +4 more sources

The Mechanical Properties of Neurospheres

Advanced Engineering Materials, 2021
Stem cell‐derived 3D tissues such as spheroids are excellent models for investigating mechanisms of tissue formation and responses to physiological and mechanical cues. Neuronal spheroids, also known as neurospheres, have attracted particular interest.
Chike K. Okwara, Roza Vaez Ghaemi, Charlotte Yu, Melissa Le, Vikramaditya G. Yadav, John M. Frostad   +5 more
openaire   +2 more sources

The neurosphere assay, a method under scrutiny [PDF]

Acta Neuropsychiatrica, 2008
Objectives:The aim of this review is to provide an overview of the fundamental features of the neurosphere assay (NSA), which was initially described in 1992, and has since been used not only to detect the presence of stem cells in embryonic and adult mammalian neural tissues, but also to study their characteristicsin vitro.
Deleyrolle, Loic P., Rietze, Rodney L., Reynolds, Brent A.   +2 more
openaire   +3 more sources

Neurosphere and neurosphere-forming cells: morphological and ultrastructural characterization

Brain Research, 2003
Despite recent advances in our understanding of neural stem cell (NSC) biology, the free-floating structures generated by these cells in vitro, the "neurospheres", have not been fully characterized. To fill this gap, we examined neurospheres and neurosphere-derived NSCs by confocal microscopy, electron microscopy (EM) and cytofluorimetry. Here, we show
BEZ A, CORSINI E, COLOMBO A, NICOSIA RF, PAGANO SF, PARATI EA, CURTI, DANIELA, BIGGIOGERA, MARCO   +7 more
openaire   +5 more sources

Simulation of the growth of neurospheres

Europhysics Letters (EPL), 2004
Under appropriate conditions, the neural stem cells are able to proliferate and to form suspended neurospheres containing stem cells and neuronal and glial progenitors in different stages of differentiation. Our lattice Monte Carlo simulations, taking into account the effect of spatial constraints and cell-cell adhesion on cell diffusion and division ...
Vladimir P. Zhdanov, Vladimir P. Zhdanov, Bengt Herbert Kasemo   +2 more
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Strengths and Limitations of the Neurosphere Culture System [PDF]

Molecular Neurobiology, 2006
After the initial reports of free-floating cultures of neural stem cells termed neurospheres (1,2), a wide array of studies using this promising culture system emerged. In theory, this was a near-perfect system for large-scale production of neural cells for use in cell replacement therapies and to assay for and characterize neural stem cells. More than
Malin Parmar, Josephine B. Jensen
openaire   +2 more sources