Results 21 to 30 of about 22,415 (298)

Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain [PDF]

Frontiers in Aging Neuroscience
IntroductionNeurosphere culture is widely used to expand neural stem and progenitor cells (NSPCs) of the nervous system. Understanding the identity of NSPCs, such as the principals involved in spatiotemporal patterning, will improve our chances of using ...
Saeideh Aran, Mohammad Ghasem Golmohammadi, Mohsen Sagha, Kamran Ghaedi   +3 more
doaj   +2 more sources

Testosterone-induced adult neurosphere growth is mediated by sexually-dimorphic aromatase expression

Frontiers in Cellular Neuroscience, 2015
We derived adult neural stem/progenitor cells (NSPCs) from the sub-ventricular zone of male and female mice to examine direct responses to principal sex hormones.
Mark Ian Ransome, Wah Chin eBoon, Wah Chin eBoon   +2 more
doaj   +2 more sources

mRNA transfection of mouse and human neural stem cell cultures. [PDF]

PLoS ONE, 2013
The use of synthetic mRNA as an alternative gene delivery vector to traditional DNA-based constructs provides an effective method for inducing transient gene expression in cell cultures without genetic modification.
Samuel McLenachan, Dan Zhang, Ana Belén Alvarez Palomo, Michael J Edel, Fred K Chen   +4 more
doaj   +5 more sources

Prolactin stimulates precursor cells in the adult mouse hippocampus. [PDF]

PLoS ONE, 2012
In the search for ways to combat degenerative neurological disorders, neurogenesis-stimulating factors are proving to be a promising area of research. In this study, we show that the hormonal factor prolactin (PRL) can activate a pool of latent precursor
Tara L Walker, Jana Vukovic, Margaretha M Koudijs, Daniel G Blackmore, Eirinn W Mackay, Alex M Sykes, Rupert W Overall, Adam S Hamlin, Perry F Bartlett   +8 more
doaj   +5 more sources

Inhibition of Neurosphere Formation in Neural Stem/Progenitor Cells by Acrylamide

Cell Transplantation, 2015
Previous studies showed that transplantation of cultured neural stem/progenitor cells (NSPCs) could improve functional recovery for various neurological diseases. This study aims to develop a stem cell-based model for predictive toxicology of development
Jong-Hang Chen, Don-Ching Lee, Mei-Shu Chen, Ying-Chin Ko, Ing-Ming Chiu   +4 more
doaj   +2 more sources

Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain

eLife, 2014
Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear.
John K Mich, Robert AJ Signer, Daisuke Nakada, André Pineda, Rebecca J Burgess, Tou Yia Vue, Jane E Johnson, Sean J Morrison   +7 more
doaj   +2 more sources

Nuclear hormone receptors control fundamental processes of human fetal neurodevelopment: Basis for endocrine disruption assessment [PDF]

Environment International
Despite growing awareness of endocrine disrupting chemicals (EDCs), knowledge gaps remain regarding their effects on human brain development. EDC risk assessment focuses primarily on EATS modalities (estrogens, androgens, thyroid hormones, and ...
Katharina Koch, Kevin Schlüppmann, Saskia Hüsken, Louisa Merit Stark, Nils Förster, Stefan Masjosthusmann, Jördis Klose, Arif Dönmez, Ellen Fritsche   +8 more
doaj   +2 more sources

A tenascin-C mimetic peptide amphiphile nanofiber gel promotes neurite outgrowth and cell migration of neurosphere-derived cells.

Acta Biomaterialia, 2016
Eric J. Berns, Z. Álvarez, Joshua E. Goldberger, J. Boekhoven, J. Kessler, H. Kuhn, S. Stupp   +6 more
semanticscholar   +3 more sources

Early Acquisition of Neural Crest Competence During hESCs Neuralization [PDF]

, 2010
Background: Neural crest stem cells (NCSCs) are a transient multipotent embryonic cell population that represents a defining characteristic of vertebrates.
Bronner-Fraser, Marianne, Cattarossi, Giulio, Cimadamore, Flavio, Curchoe, Carol Lynn, Maurer, Jochen, McKeown, Sonja J., Nilbratt, Mats, Snyder, Evan Y., Terskikh, Alexey V.   +8 more
core   +18 more sources

Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model

Frontiers in Bioengineering and Biotechnology, 2023
High failure rates in clinical trials for neurodegenerative disorders such as Alzheimer’s disease have been linked to an insufficient predictive validity of current animal-based disease models. This has created an increasing demand for alternative, human-
Eunkyung Clare Ko, Sarah Spitz, F. M. Pramotton, Olivia M. Barr, Ciana Xu, Georgios Pavlou, Shun Zhang, Alice Tsai, Anna Maaser-Hecker, Mehdi Jorfi, Se Hoon Choi, Rudolph E. Tanzi, R. Kamm   +12 more
semanticscholar   +1 more source