Results 31 to 40 of about 22,415 (298)
Journal of Biomedical Research, 2022 This study aimed to investigate the effect and mechanism of valproic acid (VPA) on the neurosphere formation in rat embryonic cortical cells. We used free-floating neurosphere formation as a model system to evaluate the VPA on the proliferation of neural
C. Qi +5 more
semanticscholar +1 more source
Human Patient-Derived Brain Tumor Models to Recapitulate Ependymoma Tumor Vasculature
Bioengineering, 2023 Despite in vivo malignancy, ependymoma lacks cell culture models, thus limiting therapy development. Here, we used a tunable three-dimensional (3D) culture system to approximate the ependymoma microenvironment for recapitulating a patient’s tumor in ...
Min D. Tang-Schomer +3 more
doaj +1 more source
Generation of Porcine Induced Neural Stem Cells Using the Sendai Virus
Frontiers in Veterinary Science, 2022 The reprogramming of cells into induced neural stem cells (iNSCs), which are faster and safer to generate than induced pluripotent stem cells, holds tremendous promise for fundamental and frontier research, as well as personalized cell-based therapies ...
Warunya Chakritbudsabong +11 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Aim: Desmoplastic infantile ganglioglioma (DIG), is a rare tumor arising mainly during the first 2 years of life. Molecular characterization of these benign yet rapidly proliferating tumors has been limited to evaluating a few mutations in few genes. Our
Michelle dePadua +10 more
doaj +1 more source
Developmental neurotoxic effects of Malathion on 3D neurosphere system
Applied and Translational Genomics, 2015 M. Salama +9 more
semanticscholar +2 more sources
Prion infection of mouse neurospheres [PDF]
Proceedings of the National Academy of Sciences, 2006 Only a few cell lines have been infected with prions, offering limited genetic diversity and sensitivity to several strains. Here we report that cultured neurospheres expressing cellular prion protein (PrP C ) can be infected with prions. Neurosphere lines isolated from the brains of mice at embryonic day 13–15 grow
George A. Carlson +5 more
openaire +3 more sources
Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb [PDF]
, 2007 Wedetermined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ...
C.H. Papadimitriou +8 more
core +4 more sources
Frontiers in Molecular Neuroscience, 2023 Alterations in adult neurogenesis are a common hallmark of neurodegenerative diseases. Therefore, understanding the molecular mechanisms that control this process is an indispensable requirement for designing therapeutic interventions addressing ...
Anna Lozano-Ureña, José M. Frade
doaj +1 more source
Cells, 2023 Glioblastoma (GBM), the most common primary malignant brain tumor, is a highly lethal form of cancer with a very limited set of treatment options. High heterogeneity in the tumor cell population and the invasive nature of these cells decrease the likely ...
Gustavo Garcia +10 more
doaj +1 more source
Membranes, 2022 Mesenchymal stem cells (MSC) are promising for regenerative medicine as they have a vast differentiation capacity, immunomodulatory properties and can be isolated from different tissues.
Daiany de Souza Dobuchak +7 more
doaj +1 more source