Results 31 to 40 of about 22,400 (295)

Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb [PDF]

, 2007
Wedetermined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ...
C.H. Papadimitriou, D. Eppstein, D.D. Sleator, D.E. Knuth, K.M. Lillis, P. Angelini, R. Dhandapani, R.B. Muhammad, T. Leighton   +8 more
core   +4 more sources

Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress

Oxidative Medicine and Cellular Longevity, 2020
The presence of glioma stem cells (GSCs), which are enriched in neurospheres, may be connected to the radioresistance of glioblastoma (GBM) due to their enhanced antioxidant defense and elevated DNA repair capacity.
Paulo R D V Godoy, Ali Pour Khavari, Marzia Rizzo, E. Sakamoto-Hojo, S. Haghdoost   +4 more
semanticscholar   +1 more source

Establishment and Characterization of Brain Cancer Primary Cell Cultures From Patients to Enable Phenotypic Screening for New Drugs

Frontiers in Pharmacology, 2022
Aim: Desmoplastic infantile ganglioglioma (DIG), is a rare tumor arising mainly during the first 2 years of life. Molecular characterization of these benign yet rapidly proliferating tumors has been limited to evaluating a few mutations in few genes. Our
Michelle dePadua, Preethi Kulothungan, Rahul Lath, Ravikanti Prasad, Kranthi Madamchetty, Shravya Atmakuri, Sravanthi Ragamouni, Mukesh Gandhari, Lakshmipathi Khandrika, Jugnu Jain, Jugnu Jain   +10 more
doaj   +1 more source

Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation [PDF]

, 2003
Neural stem cells can generate in vitro progenitors of the three main cell lineages found in the CNS. The signaling pathways underlying the acquisition of differentiated phenotypes in these cells are poorly understood.
Berridge, Michael J., Bootman, Martin D., Ciccolini, Francesca, Collins, Tony J., Lipp, Peter, Sudhoelter, Juliana   +5 more
core   +1 more source

Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival [PDF]

, 2006
There are two types of neural stem cells (NSCs). Primitive NSCs [leukemia inhibitory factor (LIF) dependent but exogenous fibroblast growth factor (FGF) 2 independent] can be derived from mouse embryonic stem (ES) cells in vitro and from embryonic day 5 ...
Chaddah, R, Ema, M, Haigh, Jody, Hitoshi, S, Nagy, A, Rossant, J, van der Kooy, D, Wada, T   +7 more
core   +3 more sources

Prion infection of differentiated neurospheres

Journal of Neuroscience Methods, 2010
Until now only a few cell lines have been proved able to propagate prions and only limited prion strains have been replicated in cell models. Neurosphere lines isolated from the brains of mice at embryonic day 14 grow as aggregates and contain CNS stem cells.
Maria Eugenia Herva, Aroa Rela�o-Gin�s, Ana Villa, Juan Mar�a Torres   +3 more
openaire   +5 more sources

Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. [PDF]

, 2005
Maternal embryonic leucine zipper kinase (MELK) was previously identified in a screen for genes enriched in neural progenitors. Here, we demonstrate expression of MELK by progenitors in developing and adult brain and that MELK serves as a marker for self-
Bajpai, Ruchi, Dougherty, Joseph D, Freije, William A, Geschwind, Daniel H, Groszer, Matthias, Imura, Tetsuya, Kelly, Theresa K, Kim, Kevin J, Kornblum, Harley I, Liu, Xin, Nakano, Ichiro, Nelson, Stanley F, Ou, Jing, Paucar, Andres A, Sofroniew, Michael V, Terskikh, Alexey V, Wu, Hong, Zewail, Amani   +17 more
core   +2 more sources

Neurogenic Stem Cell Niche in the Auditory Thalamus: In Vitro Evidence of Neural Stem Cells in the Rat Medial Geniculate Body

Life, 2023
The medial geniculate body (MGB) is a nucleus of the diencephalon representing a relevant segment of the auditory pathway and is part of the metathalamus. It receives afferent information via the inferior brachium of the inferior colliculus and transmits
Jonas Engert, Bjoern Spahn, Linda Bieniussa, Rudolf Hagen, Kristen Rak, Johannes Voelker   +5 more
doaj   +1 more source

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151

Neoplasia: An International Journal for Oncology Research, 2016
Glioblastoma (GBM) stem cells (GSCs) represent tumor-propagating cells with stem-like characteristics (stemness) that contribute disproportionately to GBM drug resistance and tumor recurrence.
Jessica Tilghman, Paula Schiapparelli, Bachuchu Lal, Mingyao Ying, Alfredo Quinones-Hinojosa, Shuli Xia, John Laterra   +6 more
doaj   +1 more source

Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death

Cancers, 2019
Glioblastoma (GBM) has a dismal prognosis and successful elimination of GBM stem cells (GSCs) is a high-priority as these cells are responsible for tumor regrowth following therapy and ultimately patient relapse.
Lorenzo Sansalone, E. Véliz, Nadia G. Myrthil, Vasileios Stathias, Winston M. Walters, Ingrid Torrens, S. Schürer, S. Vanni, R. Leblanc, R. Graham   +9 more
semanticscholar   +1 more source