Results 31 to 40 of about 17,973 (254)

Effect of Epoxomicin on 3D Neurosphere [PDF]

ScienceOpen Posters, 2014
Developmental neurotoxicity (DNT) entails the toxic effects imparted by many chemicals on brain during early childhood. Various chemicals would have their maximum effects on brains during early childhood. Some toxicants have confirmed to induce developmental toxic effects on CNS.
Khaled Youssef, Mohammed Salama, Mohamed Elhosseny, Bahaaeldin Awad, Ahmed Lotfy, Mohammed Elgamal, Hussein Sheashaa, Mohammed Sobh   +7 more
openaire   +2 more sources

Transplantation of Embryonic Neural Stem Cells and Differentiated Cells in a Controlled Cortical Impact (CCI) Model of Adult Mouse Somatosensory Cortex

Frontiers in Neurology, 2018
Traumatic brain injury (TBI) is a major cause of death worldwide. Depending on the severity of the injury, TBI can reflect a broad range of consequences such as speech impairment, memory disturbances, and premature death.
Mohammad Nasser, Mohammad Nasser, Nissrine Ballout, Sarah Mantash, Fabienne Bejjani, Farah Najdi, Naify Ramadan, Naify Ramadan, Jihane Soueid, Kazem Zibara, Kazem Zibara, Firas Kobeissy   +11 more
doaj   +1 more source

Characterisation of human gingival neural crest-derived stem cells in monolayer and neurosphere cultures [PDF]

European Cells & Materials, 2016
Neural crest (NC)-derived stem cells (NCSC) have an exceptionally wide differentiation potential, but their use in regenerative therapy has been hampered by their scarcity in adult tissues and complex isolation protocols.
BP Fournier, LS Loison-Robert, FC Ferré, GR Owen, H Larjava, L Häkkinen   +5 more
doaj   +1 more source

Synthesis of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and in vitro anti-glioma activity

Annals of Medicine, 2022
A series of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles was synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity against primary patient-derived glioblastoma 2D cells and 3D neurospheres.
Ruturajsinh M. Vala, Vasudha Tandon, Lynden G. Nicely, Luxia Guo, Yanlong Gu, Sourav Banerjee, Hitendra M. Patel   +6 more
doaj   +1 more source

Chronic wasting disease prion infection of differentiated neurospheres [PDF]

Prion, 2017
A possible strategy to develop more diverse cell culture systems permissive to infection with naturally occurring prions is to exploit culture of neurospheres from transgenic mice expressing the normal prion protein (PrP) of the native host species. Accordingly, we developed differentiated neurosphere cultures from the cervid PrP-expressing mice to ...
Yoshifumi, Iwamaru, Candace K, Mathiason, Glenn C, Telling, Edward A, Hoover   +3 more
openaire   +2 more sources

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide. [PDF]

, 2018
Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are ...
Day, Emily S, Gleghorn, Jason P, Ioele, Stephen A, Melamed, Jilian R, Morgan, Joshua T, Sims-Mourtada, Jennifer   +5 more
core   +1 more source

Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells

Protein & Cell, 2016
Living organisms are exposed to the geomagnetic field (GMF) throughout their lifespan. Elimination of the GMF, resulting in a hypogeomagnetic field (HMF), leads to central nervous system dysfunction and abnormal development in animals.
Jing-Peng Fu, Wei-Chuan Mo, Ying Liu, Perry F. Bartlett, Rong-Qiao He   +4 more
doaj   +1 more source

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells [PDF]

, 2018
Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development.
Agnese Po, Andrea Carai, Angela Mastronuzzi, Elisabetta Ferretti, Elisabetta Ferretti, Enrico De Smaele, Evelina Miele, Felice Giangaspero, Felice Giangaspero, Franco Locatelli, Franco Locatelli, Luana Abballe, Marta Moretti, Zein Mersini Besharat   +13 more
core   +9 more sources

Hedgehog pathway permissive conditions allow generation of immortal cell lines from granule cells derived from cancerous and non-cancerous cerebellum [PDF]

Open Biology, 2019
Cerebellar granule cell progenitors (GCPs) undergo proliferation in the post-natal cerebellum that is dependent on sonic hedgehog (SHH) signalling. Deregulated SHH signalling leads to type 2 medulloblastoma (MB).
Constantin Heil
doaj   +1 more source

Disease-specific, neurosphere-derived cells as models for brain disorders [PDF]

, 2010
There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses.
Abrahamsen, G., An, J., Anderson, M., Beckhouse, A.G., Bellette, B., Bennebroek, M., Cecil, R., Chalk, A.M., Cochrane, J., Cook, A.L., Fan, Y., Féron, F., Mackay-Sim, A., Mahler, S., Matigian, N., McCurdy, R., McGrath, J.J., Mellick, G.D., Murrell, W., Nouwens, A., Perry, C., Raju, J., Ravishankar, S., Silburn, P.A., Sue, C.M., Sutharsan, R., Sutherland, G.T., Vitale, A.M., Wells, C.A., Wood, S.A.   +29 more
core   +1 more source