Results 41 to 50 of about 22,400 (295)

Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR+ Populations with Stem Cell Properties

open access: yesStem Cell Reports, 2017
Characterization of non-neoplastic and malignant human stem cell populations in their native state can provide new insights into gliomagenesis. Here we developed a purification strategy to directly isolate EGFR+/− populations from human germinal matrix ...
Jessica Tome-Garcia   +13 more
doaj   +1 more source

Synthesis of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and in vitro anti-glioma activity

open access: yesAnnals of Medicine, 2022
A series of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles was synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity against primary patient-derived glioblastoma 2D cells and 3D neurospheres.
Ruturajsinh M. Vala   +6 more
doaj   +1 more source

DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. [PDF]

open access: yes, 2017
INTRODUCTION:The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways.
Chidambaran, Vidya   +8 more
core   +1 more source

GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models

open access: yesAging, 2019
Glucocerebrosidase (GBA) mutations are the most important genetic risk factor for the development of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase).
C. Morén   +10 more
semanticscholar   +1 more source

Involvement of NOS2 Activity on Human Glioma Cell Growth, Clonogenic Potential, and Neurosphere Generation

open access: yesInternational Journal of Molecular Sciences, 2018
Aberrant nitric oxide synthase 2 (NOS2) expression has been suggested as an interesting therapeutic target that is being implicated as a component of the molecular profile of several human malignant tumors, including glioblastoma, which is the most ...
P. Palumbo   +7 more
semanticscholar   +1 more source

Hedgehog pathway permissive conditions allow generation of immortal cell lines from granule cells derived from cancerous and non-cancerous cerebellum [PDF]

open access: yesOpen Biology, 2019
Cerebellar granule cell progenitors (GCPs) undergo proliferation in the post-natal cerebellum that is dependent on sonic hedgehog (SHH) signalling. Deregulated SHH signalling leads to type 2 medulloblastoma (MB).
Constantin Heil
doaj   +1 more source

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide. [PDF]

open access: yes, 2018
Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are ...
Day, Emily S   +5 more
core   +1 more source

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells [PDF]

open access: yes, 2018
Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development.
Agnese Po   +13 more
core   +9 more sources

Nuclear Factor-kappaB controls the reaggregation of 3D neurosphere cultures in vitro [PDF]

open access: yesEuropean Cells & Materials, 2006
The approach of reaggregation involves the regeneration and self-renewal of histotypical 3D spheres from isolated tissue kept in suspension culture. Reaggregated spheres can be used as tumour, genetic, biohybrid and neurosphere models.
D Widera   +4 more
doaj  

Teleprogramming Service Provides Safe and Remote Stimulation Options for Patients with DRG-S and SCS Implants

open access: yesJournal of Pain Research, 2021
Timothy R Deer,1 Michael F Esposito,2 Eric G Cornidez,3 Udoka Okaro,4 Marie E Fahey,4 Kenneth B Chapman5 1Spine and Nerve Center of the Virginias, Charleston, WV, USA; 2Florida Pain Institute, Melbourne, FL, USA; 3Pain Institute of Southern Arizona ...
Deer TR   +5 more
doaj  

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