Results 41 to 50 of about 22,400 (295)
Stem Cell Reports, 2017 Characterization of non-neoplastic and malignant human stem cell populations in their native state can provide new insights into gliomagenesis. Here we developed a purification strategy to directly isolate EGFR+/− populations from human germinal matrix ...
Jessica Tome-Garcia +13 more
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Annals of Medicine, 2022 A series of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles was synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity against primary patient-derived glioblastoma 2D cells and 3D neurospheres.
Ruturajsinh M. Vala +6 more
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DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. [PDF]
, 2017 INTRODUCTION:The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways.
Chidambaran, Vidya +8 more
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GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models
Aging, 2019 Glucocerebrosidase (GBA) mutations are the most important genetic risk factor for the development of Parkinson disease (PD). GBA encodes the lysosomal enzyme glucocerebrosidase (GCase).
C. Morén +10 more
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International Journal of Molecular Sciences, 2018 Aberrant nitric oxide synthase 2 (NOS2) expression has been suggested as an interesting therapeutic target that is being implicated as a component of the molecular profile of several human malignant tumors, including glioblastoma, which is the most ...
P. Palumbo +7 more
semanticscholar +1 more source
Hedgehog pathway permissive conditions allow generation of immortal cell lines from granule cells derived from cancerous and non-cancerous cerebellum [PDF]
Open Biology, 2019 Cerebellar granule cell progenitors (GCPs) undergo proliferation in the post-natal cerebellum that is dependent on sonic hedgehog (SHH) signalling. Deregulated SHH signalling leads to type 2 medulloblastoma (MB).
Constantin Heil
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Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide. [PDF]
, 2018 Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are ...
Day, Emily S +5 more
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Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells [PDF]
, 2018 Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development.
Agnese Po +13 more
core +9 more sources
Nuclear Factor-kappaB controls the reaggregation of 3D neurosphere cultures in vitro [PDF]
European Cells & Materials, 2006 The approach of reaggregation involves the regeneration and self-renewal of histotypical 3D spheres from isolated tissue kept in suspension culture. Reaggregated spheres can be used as tumour, genetic, biohybrid and neurosphere models.
D Widera +4 more
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Journal of Pain Research, 2021 Timothy R Deer,1 Michael F Esposito,2 Eric G Cornidez,3 Udoka Okaro,4 Marie E Fahey,4 Kenneth B Chapman5 1Spine and Nerve Center of the Virginias, Charleston, WV, USA; 2Florida Pain Institute, Melbourne, FL, USA; 3Pain Institute of Southern Arizona ...
Deer TR +5 more
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