Results 61 to 70 of about 22,400 (295)
A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses [PDF]
, 2016 Background. Glioblastoma (GBM) is the most common primary brain tumor, with dismal prognosis. The failure of drug–radiation combinations with promising preclinical data to translate into effective clinical treatments may relate to the use of simplified
Chalmers, Anthony +4 more
core +2 more sources
A glioblastoma neurosphere line with alternative lengthening of telomeres [PDF]
Acta Neuropathologica, 2013 Neoplastic cells must maintain telomeres in order to replicate extensively, often by inducing telomerase activity. However, some tumors use a telomerase-independent mechanism dependent upon homologous recombination known as alternative lengthening of telomeres (ALT) [1].
Eric H. Raabe +11 more
openaire +3 more sources
In vitro neurosphere formation correlates with poor survival in glioma
IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2018 Sphere formation is an indicator of tumor aggressiveness independent of the tumor grade; however, its relation to progression‐free survival (PFS) is less known. This study was designed to assess the neurosphere forming ability among low grade glioma (LGG)
Padmakrishnan C Jayakrishnan +7 more
semanticscholar +1 more source
Neural derivation of human dental pulp stem cells via neurosphere technique.
Bratislava Medical Journal, 2018 INTRODUCTION Human dental pulp stem cells (hDPSCs) are multipotent stem cells providing an autologous noninvasive cell source. The study evaluates the neurogenic potential of hDPSCs using neural growth factor inducers and neurosphere technique ...
M. N. Bojnordi +3 more
semanticscholar +1 more source
Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. [PDF]
PLoS ONE, 2012 Stem cell (SC) lines that capture the genetics of disease susceptibility provide new research tools. To assess the utility of mouse central nervous system (CNS) SC-containing neurosphere cultures for studying heritable neurodegenerative disease, we ...
Miranda E Orr +4 more
doaj +1 more source
Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth
Advanced Functional Materials, EarlyView.Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung +8 more
wiley +1 more source
Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]
, 2009 BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P +11 more
core +1 more source
OncoTarget, 2017 Nitric oxide has been implicated in biology and progression of glioblastoma (GBM) being able to influence the cellular signal depending on the concentration and duration of cell exposure.
P. Palumbo +9 more
semanticscholar +1 more source
Chronic wasting disease prion infection of differentiated neurospheres [PDF]
Prion, 2017 A possible strategy to develop more diverse cell culture systems permissive to infection with naturally occurring prions is to exploit culture of neurospheres from transgenic mice expressing the normal prion protein (PrP) of the native host species. Accordingly, we developed differentiated neurosphere cultures from the cervid PrP-expressing mice to ...
Edward A. Hoover +3 more
openaire +3 more sources
Frontiers in Molecular Neuroscience, 2019 Depression is a debilitating psychiatric disorder with a high rate of relapse and a low rate of response to antidepressant treatment. There is a dearth of new antidepressants due to an incomplete understanding of the molecular mechanisms involved in its ...
Nitin Khandelwal +5 more
doaj +1 more source