Results 61 to 70 of about 22,415 (298)

Disease-specific, neurosphere-derived cells as models for brain disorders [PDF]

, 2010
There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses.
Abrahamsen, G., An, J., Anderson, M., Beckhouse, A.G., Bellette, B., Bennebroek, M., Cecil, R., Chalk, A.M., Cochrane, J., Cook, A.L., Fan, Y., Féron, F., Mackay-Sim, A., Mahler, S., Matigian, N., McCurdy, R., McGrath, J.J., Mellick, G.D., Murrell, W., Nouwens, A., Perry, C., Raju, J., Ravishankar, S., Silburn, P.A., Sue, C.M., Sutharsan, R., Sutherland, G.T., Vitale, A.M., Wells, C.A., Wood, S.A.   +29 more
core   +1 more source

Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques [PDF]

, 2014
<b>Background</b><p></p> Myelination is a very complex process that requires the cross talk between various neural cell types.
Anderson, Kurt I, Barnett, Susan C, Edgar, Julia M, Ioannidou, Kalliopi, Strachan, David   +4 more
core   +2 more sources

Effect of Epoxomicin on 3D Neurosphere [PDF]

, 2014
Developmental neurotoxicity (DNT) entails the toxic effects imparted by many chemicals on brain during early childhood. Various chemicals would have their maximum effects on brains during early childhood. Some toxicants have confirmed to induce developmental toxic effects on CNS.
Khaled Youssef, Mohammed Salama, Mohamed Elhosseny, Bahaaeldin Awad, Ahmed Lotfy, Mohammed Elgamal, Hussein Sheashaa, Mohammed Sobh   +7 more
openaire   +2 more sources

Production of Neurospheres from CNS Tissue [PDF]

, 2008
The relatively recent discovery of persistent adult neurogenesis has led to the experimental isolation and characterization of central nervous system neural stem cell populations. Protocols for in vitro analysis and expansion of neural stem cells are crucial for understanding their properties and defining characteristics.
Dennis A. Steindler, Heather H. Ross, Gregory P. Marshall, Tong Zheng, Oleg Suslov, Eric D. Laywell   +5 more
openaire   +3 more sources

A glioblastoma neurosphere line with alternative lengthening of telomeres [PDF]

Acta Neuropathologica, 2013
Neoplastic cells must maintain telomeres in order to replicate extensively, often by inducing telomerase activity. However, some tumors use a telomerase-independent mechanism dependent upon homologous recombination known as alternative lengthening of telomeres (ALT) [1].
Eric H. Raabe, Yazmin Odia, Xing Gang Mao, Christopher M. Heaphy, Alan K. Meeker, Weijie Poh, Yuchen Jiao, Ping An, Qian Chu, Fausto J. Rodriguez, Charles G. Eberhart, Karisa C. Schreck   +11 more
openaire   +3 more sources

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]

, 2009
BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P, Goldstein, Andrew S, Hahm, Scott A, Haider, Maahum, Head, Christian S, Perner, Sven, Reiter, Robert E, Rubin, Mark A, Sun, Wenyi, Tran, Chau P, Witte, Owen N, Zhang, Bao   +11 more
core   +1 more source

Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR+ Populations with Stem Cell Properties

Stem Cell Reports, 2017
Characterization of non-neoplastic and malignant human stem cell populations in their native state can provide new insights into gliomagenesis. Here we developed a purification strategy to directly isolate EGFR+/− populations from human germinal matrix ...
Jessica Tome-Garcia, Rut Tejero, German Nudelman, Raymund L. Yong, Robert Sebra, Huaien Wang, Mary Fowkes, Margret Magid, Martin Walsh, Violeta Silva-Vargas, Elena Zaslavsky, Roland H. Friedel, Fiona Doetsch, Nadejda M. Tsankova   +13 more
doaj   +1 more source

Direct generation of neurosphere-like cells from human dermal fibroblasts. [PDF]

PLoS ONE, 2011
Neural stem cell (NSC) transplantation replaces damaged brain cells and provides disease-modifying effects in many neurological disorders. However, there has been no efficient way to obtain autologous NSCs in patients.
Soon-Tae Lee, Kon Chu, Keun-Hwa Jung, Young-Mi Song, Daejong Jeon, Seung U Kim, Manho Kim, Sang Kun Lee, Jae-Kyu Roh   +8 more
doaj   +1 more source

Docosahexaenoic Acid and Melatonin Prevent Impaired Oligodendrogenesis Induced by Intrauterine Growth Restriction (IUGR)

Biomedicines, 2022
In this study, our aims were to characterize oligodendrogenesis alterations in fetuses with intrauterine growth restriction (IUGR) and to find therapeutic strategies to prevent/treat them using a novel rabbit in vitro neurosphere culture.
Britta Anna Kühne, Paula Vázquez-Aristizabal, Mercè Fuentes-Amell, Laura Pla, Carla Loreiro, Jesús Gómez-Catalán, Eduard Gratacós, Miriam Illa, Marta Barenys   +8 more
doaj   +1 more source

Requirement of Pax6 for the integration of guidance cues in cell migration [PDF]

, 2017
Data accessibility. Cell trajectories data and a summary of directedness and angle values are deposited at Dryad: http://dx.doi.org/10.5061/dryad.53512.
Arocena, Miguel, Collinson, Jon Martin, Rajnicek, Ann M   +2 more
core   +1 more source