Results 71 to 80 of about 17,973 (254)

Differential Roles of Environmental Enrichment in Alzheimer’s Type of Neurodegeneration and Physiological Aging

Frontiers in Aging Neuroscience, 2017
Impairment of hippocampal adult neurogenesis in aging or degenerating brain is a well-known phenomenon caused by the shortage of brain stem cell pool, alterations in the local microenvironment within the neurogenic niches, or deregulation of stem cell ...
Vladimir V. Salmin, Yulia K. Komleva, Yulia K. Komleva, Natalia V. Kuvacheva, Natalia V. Kuvacheva, Andrey V. Morgun, Elena D. Khilazheva, Elena D. Khilazheva, Olga L. Lopatina, Olga L. Lopatina, Elena A. Pozhilenkova, Elena A. Pozhilenkova, Konstantin A. Shapovalov, Yulia A. Uspenskaya, Alla B. Salmina, Alla B. Salmina   +15 more
doaj   +1 more source

Regulation of progenitor cell proliferation and neuronal differentiation in enteric nervous system neurospheres. [PDF]

PLoS ONE, 2013
Enteric nervous system (ENS) progenitor cells isolated from mouse and human bowel can be cultured in vitro as neurospheres which are aggregates of the proliferating progenitor cells, together with neurons and glial cells derived from them. To investigate
Sokratis Theocharatos, David J Wilkinson, Sarah Darling, Bettina Wilm, Simon E Kenny, David Edgar   +5 more
doaj   +1 more source

Zika virus disrupts molecular fingerprinting of human neurospheres [PDF]

Scientific Reports, 2017
AbstractZika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is ...
Patricia P. Garcez, Juliana Minardi Nascimento, Janaina Mota de Vasconcelos, Rodrigo Madeiro da Costa, Rodrigo Delvecchio, Pablo Trindade, Erick Correia Loiola, Luiza M. Higa, Juliana S. Cassoli, Gabriela Vitória, Patricia C. Sequeira, Jaroslaw Sochacki, Renato S. Aguiar, Hellen Thais Fuzii, Ana M. Bispo de Filippis, João Lídio da Silva Gonçalves Vianez Júnior, Amilcar Tanuri, Daniel Martins-de-Souza, Stevens K. Rehen   +18 more
openaire   +2 more sources

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Advanced Science, EarlyView.
Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song, Zuomeng Wu, Yixiang Dong, Yunxiong Fang, Shiyu Bian, Daokuan Wang, Huang Fang, Yunlei Liu, Wang Ying, Jun Qian, Tianyu Han, Cailiang Shen   +11 more
wiley   +1 more source

Regulation of Onecut2 by miR-9-5p in Japanese encephalitis virus infected neural stem/progenitor cells

Microbiology Spectrum
Japanese encephalitis virus (JEV) is one of the major neurotropic viral infections that is known to dysregulate the homeostasis of neural stem/progenitor cells (NSPCs) and depletes the stem cell pool.
Shivangi Sharma, Atreye Majumdar, Anirban Basu   +2 more
doaj   +1 more source

Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations [PDF]

, 2001
Multipotent stem cells are clonal cells that self-renew as well as differentiate to regenerate adult tissues. Whereas stem cells and their fates are known by unique genetic marker studies, the fate and function of these cells are best studied by their ...
Anderson­, David J., Gage­, Fred, Weissman­, Irving L.   +2 more
core   +1 more source

Chikungunya virus infection induces ultrastructural changes and impaired neuronal differentiation of human neurospheres [PDF]

, 2023
Thaíse Yasmine Vasconcelos de Lima Cavalcanti, Elisa de Almeida Neves Azevedo, Morganna Costa Lima, Karina Lidiane Alcântara Saraiva, Rafael Freitas de Oliveira França   +4 more
openalex   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3. [PDF]

PLoS ONE, 2017
The growth factor and cytokine regulated transcription factor STAT3 is required for the self-renewal of several stem cell types including tumor stem cells from glioblastoma.
Maureen M Sherry-Lynes, Sejuti Sengupta, Shreya Kulkarni, Brent H Cochran   +3 more
doaj   +1 more source

Cryopreservation of Neurospheres Derived from Human Glioblastoma Multiforme [PDF]

Stem Cells, 2009
Abstract Cancer stem cells have been shown to initiate and sustain tumor growth. In many instances, clinical material is limited, compounded by a lack of methods to preserve such cells at convenient time points. Although brain tumor-initiating cells grown in a spheroid manner have been shown to maintain their integrity through serial ...
Chong, Y.-K., Toh, T.-B., Zaiden, N., Poonepalli, A., Siew, H.L., Ong, C.E.L., Yu, Y., Tan, P.B., See, S.-J., Ng, W.-H., Ng, I., Hande, M.P., Oi, L.K., Ang, B.-T., Tang, C.   +14 more
openaire   +2 more sources