Results 81 to 90 of about 22,400 (295)

FKBP38 Regulates Self-Renewal and Survival of GBM Neurospheres

Cells, 2023
Glioblastoma is the most common malignant primary brain tumor. The outcome is dismal, despite the multimodal therapeutic approach that includes surgical resection, followed by radiation and chemotherapy. The quest for novel therapeutic targets to treat glioblastoma is underway.
Aimee L. Dowling, Stuart Walbridge, Celine Ertekin, Sriya Namagiri, Krystal Camacho, Ashis Chowdhury, Jean-Paul Bryant, Eric Kohut, John D. Heiss, Desmond A. Brown, Sangamesh G. Kumbar, Yeshavanth Kumar Banasavadi-Siddegowda   +11 more
openaire   +3 more sources

Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction

Stem Cells Translational Medicine, 2021
The aim of this study was to develop a rabbit neurosphere culture to characterize differences in basic processes of neurogenesis induced by intrauterine growth restriction (IUGR).
Marta Barenys, Miriam Illa, Maxi Hofrichter, Carla Loreiro, Laura Pla, Jördis Klose, Britta Anna Kühne, Jesús Gómez‐Catalán, Jan Matthias Braun, Fatima Crispi, Eduard Gratacós, Ellen Fritsche   +11 more
doaj   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. [PDF]

, 2019
Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB).
Abagyan, Ruben, Chahal, Kirti Kandhwal, Chen, Clark C, Durden, Donald L, Kufareva, Irina, Li, Jie, Parle, Milind, Wechsler-Reya, Robert J   +7 more
core   +1 more source

Prolactin stimulates precursor cells in the adult mouse hippocampus. [PDF]

PLoS ONE, 2012
In the search for ways to combat degenerative neurological disorders, neurogenesis-stimulating factors are proving to be a promising area of research. In this study, we show that the hormonal factor prolactin (PRL) can activate a pool of latent precursor
Tara L Walker, Jana Vukovic, Margaretha M Koudijs, Daniel G Blackmore, Eirinn W Mackay, Alex M Sykes, Rupert W Overall, Adam S Hamlin, Perry F Bartlett   +8 more
doaj   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone [PDF]

, 2019
In the adult rodent brain, the continuous production of new neurons by neural stem/progenitor cells (NSPCs) residing in specialized neurogenic niches and their subsequent integration into pre-existing cerebral circuitries supports odour discrimination ...
Biagioni, Stefano, Cacci, Emanuele, Gioia, Roberta, Lupo, Giuseppe, Nisi, PAOLA SERENA   +4 more
core   +1 more source

Differentiation of neurosphere after transplantation into the damaged spinal cord

Journal of Medicine and Life, 2023
This study aimed to compare the differentiation and survival of human neural stem/progenitor cells of various origins in vitro and after transplantation into the injured spinal cord of laboratory animals. Rats with simulated spinal cord injury were transplanted with neurosphere cells obtained by directed differentiation of HUES6 cell lines ...
Gramatiuk, Svetlana Mykolaiivna, Ivanova, Yulia Viktorovna, Hudyma, Arsen Arsenievich, Sargsyan, Karine, Kryvoruchko, Igor Andreevich, Puliaieva, Inna Sergeevna   +5 more
openaire   +2 more sources

Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1

, 2008
Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a ...
Armstrong, D.L., Boerkoel, C.F., Choi, K., Clewing, J.M., Deguchi, K., Elizondo, L.I., Fujita, Y., Hirano, R., Huang, C., Inoue, K., Kanemura, Y., Lou, S., Lucke, T., Marwedel, K.M., Northrop, J., Okano, H., Powell, R., SantaCruz, K., Sloan, E.A., van der Kooy, D., Willaime-Morawek, S.   +20 more
core   +1 more source

Regulation of progenitor cell proliferation and neuronal differentiation in enteric nervous system neurospheres. [PDF]

PLoS ONE, 2013
Enteric nervous system (ENS) progenitor cells isolated from mouse and human bowel can be cultured in vitro as neurospheres which are aggregates of the proliferating progenitor cells, together with neurons and glial cells derived from them. To investigate
Sokratis Theocharatos, David J Wilkinson, Sarah Darling, Bettina Wilm, Simon E Kenny, David Edgar   +5 more
doaj   +1 more source