Results 161 to 170 of about 521,894 (411)

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

Advanced Science, EarlyView.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao, Siwen Chen, Hua Chao, Zihao Li, Hao Yang, Dongying Chen, Sifang Li, Shuai Zhang, Jingyu Zhang, Jianru Wang, Zemin Li, Xiang Li, Zhongping Zhan, Tangming Guan, Yiwen Zhang, Wende Li, Hui Liu   +16 more
wiley   +1 more source

Cervical subaxial spine uni-facet dislocation occurring in an infant

Interdisciplinary Neurosurgery, 2019
While pediatric spinal injuries account for between 1 and 10% of all spinal injuries
Aftab Younus, Dr, FC Orthopedics (SA), Adrian Kelly, Dr, MMed Neurosurgery cum laude (SMU), FC Neurosurgery (SA), Patrick Lekgwara, FC Neurosurgery (SA)   +2 more
doaj  

Clinical Correlates of High Cervical Fractional Anisotropy in Acute Cervical Spinal Cord Injury [PDF]

, 2015
Objective: Fractional anisotropy (FA) of the high cervical cord (C1-C2), rostral to the injury site, correlates with upper limb function in patients with chronic cervical spinal cord injury (SCI).
Eckardt, Gerald, Kurpad, Shekar N., Schmit, Brian D., Vedantam, Aditya, Wang, Marjorie C.   +4 more
core   +1 more source

Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

Advanced Science, EarlyView.
A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu, Zhongzheng Sun, Yingchao Liu, Jiang Liu, Linpei Guo, Guojing Pei, Ying Jiang, Baowang Miao, Zhen Li, Ping Zhang, Dongqi Tang, Wen Zhang, Chengwei Wang   +12 more
wiley   +1 more source

Reappraisal of cerebellopontine angle medulloblastomas: Report of a fatal case and lessons learned

Interdisciplinary Neurosurgery, 2018
CPA Medulloblastomas are rare in adults. We describe a case of medulloblastoma in the right CPA in a middle aged male patient who presented with short history and was preoperatively diagnosed as vestibular schwannoma.
Sachin Ranganatha Goudihalli, M.Ch. Neurosurgery, Ashis Pathak, M.Ch. Neurosurgery, Rahat Brar, M.D. Radiology, Irneet Mundi, M.D. Pathology   +3 more
doaj  

Framework and Bio-Mechanical Model for a Per-Operative Image-Guided Neuronavigator Including 'Brain-Shift' Compensation [PDF]

arXiv, 2006
In this paper we present a methodology to adress the problem of brain tissue deformation referred to as "brainshift". This deformation occurs throughout a neurosurgery intervention and strongly alters the accuracy of the neuronavigation systems used to date in clinical routine which rely solely on preoperative patient imaging to locate the surgical ...
arxiv  

Artificial Intelligent‐Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonally Responsive SERS Probe

Advanced Science, EarlyView.
This study presents a novel approach for intraoperative identification of the IDH1 genotype in glioma patients using a surface‐enhanced Raman scattering (SERS) probe to measure glutathione and hydrogen peroxide. By integrating AI‐driven deep learning algorithms, the method achieves rapid and accurate genotype differentiation, offering the potential to ...
Hang Yin, Xin Zhang, Zheng Zhao, Chong Cao, Minhua Xu, Suhongrui Zhou, Tian Xuan, Ziyi Jin, Limei Han, Yang Fan, Cong Wang, Xiao Zhu, Ying Mao, Jinhua Yu, Cong Li   +14 more
wiley   +1 more source

Variation in academic neurosurgery departments’ #neurosurgery social media influence

World Neurosurgery: X, 2023
Background: Social media use is increasingly common among academic neurosurgery departments, but its relationship with academic metrics remains underexamined. Methods: We examine the relationship between American academic neurosurgery departments’ number
Michael B. Cloney, Benjamin Hopkins, Anastasios Roumeliotis, Najib El Tecle, Nader S. Dahdaleh   +4 more
doaj  

Framework for a low-cost intra-operative image-guided neuronavigator including brain shift compensation [PDF]

Dans Proceedings - 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society., Lyon : France (2007), 2007
In this paper we present a methodology to address the problem of brain tissue deformation referred to as 'brain-shift'. This deformation occurs throughout a neurosurgery intervention and strongly alters the accuracy of the neuronavigation systems used to date in clinical routine which rely solely on pre-operative patient imaging to locate the surgical ...
arxiv  

Intraoperative Fast Adaptive Focus Tracking Robotic OCT Enables Real‐Time Tumor Grading and Large‐Area Microvascular Imaging in Human Spinal Cord Surgery

Advanced Science, EarlyView.
The fast adaptive focus tracking robotic optical coherence tomography (FACT‐ROCT) offers real‐time, high‐resolution imaging of spinal cord tumors during surgery. By reducing motion artifacts with robotics and adaptive focal tracking, it accurately differentiates tumor grades using a novel attenuation coefficient marker and reveals critical ...
Bin He, Yuzhe Ying, Yejiong Shi, Zhe Meng, Zichen Yin, Zhengyu Chen, Zhangwei Hu, Ruizhi Xue, Linkai Jing, Yang Lu, Zhenxing Sun, Weitao Man, Youtu Wu, Dan Lei, Ning Zhang, Guihuai Wang, Ping Xue   +16 more
wiley   +1 more source