Results 41 to 50 of about 9,013 (209)

Neurosyphilis Concurrently Presenting With Limbic Encephalitis and Normal Pressure Hydrocephalus: A Case Report

Neuropsychopharmacology Reports, Volume 46, Issue 4, December 2026.
We report a case of neurosyphilis characterized by early‐onset dementia, limbic encephalitis, and normal pressure hydrocephalus. Psychiatrists should be aware of the possibility of neurosyphilis in such cases. ABSTRACT Background Neurosyphilis may present with a variety of clinical symptoms and neuroimaging findings and is thus likely to be overlooked.
Naoki Obata, Kenshi Terajima, Gen Miura, Yuta Muratake, Shun Irie, Yuichiro Watanabe   +5 more
wiley   +1 more source

Meningovascular neurosyphilis with basilar artery thrombosis in HIV patient

Journal of Infection and Public Health, 2018
Currently, neurosyphilis is an uncommon disease and may occur at any stage of syphilis. Co-infection of syphilis with HIV can affect the clinical course.
Edgar Perez Barragán, Elena Urdez Hernández, Bernardo Pérez Orozco, Mariela Sánchez González   +3 more
doaj   +1 more source

Minimizing Off‐Target Effects of CRISPR‐Cas9 With Optimized sgRNA: Evaluation of Efficiency and Specificity in the Tumor Protein 53 (TP53) Region

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2677-2689, October 2026.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) – Cas9‐based genome editing has emerged as a widely used tool across various disciplines, ranging from molecular biology to gene therapy. This revolutionary technology, which enables precise gene editing, represents a significant advancement in biotechnology, opening new frontiers for ...
Ali Mertcan Köse, Monia Ranalli, Drenka Trivanovic, Irina Maslovaric   +3 more
wiley   +1 more source

The Syphilis Ward: An Overlooked Turning Point in Sigmund Freud's Early Medical Career

JEADV Clinical Practice, Volume 5, Issue 3, Page 1008-1009, September 2026.
ABSTRACT Historians of medicine have traditionally identified Sigmund Freud's encounter with Jean‐Martin Charcot at the Salpêtrière in Paris (1885–1886) as the decisive turning point in his intellectual development. Yet an earlier and largely overlooked phase of his medical formation may have played an equally formative role: his clinical service in ...
Bruno Halioua, Charles Taieb
wiley   +1 more source

Neurosyphilis with psychotic symptoms and Parkinsonism in a young girl [PDF]

, 2015
Li Yin,* Shoukang Zou,* Yi Huang Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, People’s Republic of China *These authors contributed equally to this work Abstract: A 15-year-old girl with neurosyphilis was ...
Huang Y, Zou S, Yin L
core  

Research progress on blood-brain barrier disruption mechanisms and diagnostic biomarkers in neurosyphilis

Pifu-xingbing zhenliaoxue zazhi
Treponema pallidum is capable of invading the central nervous system, thereby causing neurosyphilis. The pathogenesis of neurosyphilis is closely related to the ability of T.pallidum to penetrate the blood-brain barrier.
HE Jiazhen, YANG Ridong, HUANG Maofang, YE Xingdong, WANG Huanli   +4 more
doaj   +1 more source

Prediction Model for Mild Cognitive Impairment in Older Chinese Patients With Cerebral Small Vessel Disease Based on XGBoost Algorithms and Shapley Additive Explanations

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
An interpretable XGBoost‐SHAP model predicted MoCA‐defined cognitive impairment in older patients with cerebral small vessel disease and identified reduced IGF‐1 as the leading predictor. The model showed strong validation performance and clinical utility, supporting early risk stratification.
Peng Gao, Jingjing Su, Xiaoming Ma, Xinwei Ma, Yujia Chen, Jiahui Shen, Yijie Wu, Cheng Shi, Jingwei Li   +8 more
wiley   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

CARE-NS, a research strategy for neurosyphilis

Frontiers in Medicine, 2023
Neurosyphilis is a major clinical manifestation of syphilis. In recent years, an increase in neurosyphilis cases has been reported in many countries.
Fang-Zhi Du, Xu Zhang, Rui-Li Zhang, Qian-Qiu Wang   +3 more
doaj   +1 more source

Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link

The FEBS Journal, Volume 293, Issue 15, Page 4660-4679, August 2026.
Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello, Maria Cristiano, Ilaria Di Nardo, Ida Palumbo, Erika Piccolo, Rosario Oliva, Andrea Bosso, Aldo Donizetti, Eugenio Notomista, Elio Pizzo   +9 more
wiley   +1 more source