Results 181 to 190 of about 1,668,634 (294)

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Transcriptomic resources and functional validation of RNAi in the cabbage seedpod weevil, Ceutorhynchus obstrictus

Pest Management Science, EarlyView.
Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis, Triin Kallavus, Éricmar Avila Dos Santos, Liina Soonvald, Riina Kaasik, Silva Vilumets, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +8 more
wiley   +1 more source

Research Progress on Pathogenesis, Modern Interventions and Neuromodulatory Mechanisms of Acupuncture for Tinnitus. [PDF]

Int J Gen Med
Xu J, Hu W, Jiang Y, Wang W, Li L, Xing Q.   +5 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Current Updates on Pharmacotherapy for Obstructive Sleep Apnea. [PDF]

J Rhinol
Kim SW.
europepmc   +1 more source

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, EarlyView.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

Pregabalin beyond pain: A neuroprotective alternative in peripheral nerve injury. [PDF]

Clinics (Sao Paulo)
Alcántara Montero A.
europepmc   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Decoding autophagy in neuro-tumor crosstalk: from underlying mechanisms to translational opportunities. [PDF]

Theranostics
Cheng H, Li H, Liu P, Jin X, Qu Y, Liu B, Li A.   +6 more
europepmc   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source