Results 221 to 230 of about 309,227 (327)
Analyzing the ‘Bradykinesia Complex’ in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Bradykinesia is the hallmark sign of parkinsonism. We recently proposed redefining bradykinesia as a complex of motor abnormalities, each reflecting separate pathophysiological elements. Objective To analyze the ‘bradykinesia complex’ in Parkinson's disease (PD) and healthy elderly individuals.
Giulia Paparella +9 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Friedreich's ataxia is a rare, neurodegenerative, multisystem disorder. While ataxia is a hallmark, non‐ataxia signs, including muscle weakness, spasticity, and dysphagia are equally disabling. The Inventory of Non‐Ataxia Signs (INAS) is a symptom list transformable to a 16‐item count.
Stella Andrea Lischewski +23 more
wiley +1 more source
Movement Disorders, EarlyView.The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger +1 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Postural abnormality (PA) is a key motor symptom in Parkinson's disease (PD) that leads to disability and death. However, the pathophysiology underlying PA is still unknown. Objective The objective of this study was to explore the neural patterns behind PAs and measures toward functional restoration using repetitive transcranial ...
Zhuang Wu +9 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Disease‐modifying treatments are a critical unmet need in Parkinson's disease (PD). Phase 2 futility trials using the Simon two‐stage design offer an efficient strategy to evaluate candidate treatments in an early PD population. Objective The aim was to assess the feasibility of Simon two‐stage futility trials in early, levodopa ...
Marcus W. Koch +12 more
wiley +1 more source
Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Constipation is a risk factor for the onset and accelerated progression of Parkinson's disease (PD), but the mechanisms underlying this association are unknown. Neuroinflammation in PD has been demonstrated in postmortem and neuroimaging studies; however, its relationship with constipation has not been investigated.
Marta Camacho +8 more
wiley +1 more source