Results 231 to 240 of about 19,535 (297)

Somato‐Cognitive Action Network in Focal Dystonia

open access: yesMovement Disorders, EarlyView.
Abstract Background The central pathology causing idiopathic focal dystonia remains unclear. The recently identified somato‐cognitive action network (SCAN) has been implicated. Objective We tested whether the effector‐agnostic SCAN may constitute a central pathology shared across dystonia subtypes, whereas the effector‐specific regions in the primary ...
Yuchao Wang   +8 more
wiley   +1 more source

Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies

open access: yesMovement Disorders, EarlyView.
Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Lachlan Churchill   +6 more
wiley   +1 more source

Brain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy

open access: yesMovement Disorders, EarlyView.
Abstract Background Clinical progression rate is the typical primary endpoint measure in progressive supranuclear palsy (PSP) clinical trials. Objectives This longitudinal multicohort study investigated whether baseline clinical severity and regional brain atrophy could predict clinical progression in PSP–Richardson's syndrome (PSP‐RS).
Andrea Quattrone   +424 more
wiley   +1 more source

Allogeneic Bone Marrow‐Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial

open access: yesMovement Disorders, EarlyView.
Abstract Background Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo‐hMSCs) may reduce neuroinflammation and improve motor symptoms. Objectives To evaluate the efficacy of repeated intravenous doses of 10 × 106/kg allo‐hMSCs in improving motor symptoms in patients
Mya C. Schiess   +15 more
wiley   +1 more source

Laparoscopic radical prostatectomy: Washington University initial experience and prospective evaluation of quality of life [PDF]

open access: yes, 2004
Chen, Cathy   +7 more
core   +2 more sources

Patient‐Derived Neurons Exhibit α‐Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein–Associated Neurodegeneration

open access: yesMovement Disorders, EarlyView.
Abstract Background Mitochondrial membrane protein–associated neurodegeneration (MPAN) from the neurodegeneration with brain iron accumulation (NBIA) family is a rare neurodegenerative disease marked by α‐synuclein aggregation, brain iron accumulation, and midbrain dopaminergic neuron degeneration.
Leonie M. Heger   +18 more
wiley   +1 more source

A Novel α‐Synuclein K58N Missense Variant in a Patient with Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α‐synuclein (aSyn), are linked to rare familial forms of PD. Objective Our goal was to assess the clinical presentation and the biological effects of a novel K58N ...
Mohammed Al‐Azzani   +24 more
wiley   +1 more source

Cortical and Corticomuscular Beta‐Gamma Phase‐Amplitude Coupling During Different Locomotion States and the Effects of Levodopa in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Phase‐amplitude coupling (PAC) in the beta‐gamma range has emerged as a promising electrophysiological biomarker of Parkinson's disease (PD). Objective This study aims to investigate how levodopa and locomotion modulate cortical (central electroencephalogram [cEEG]) and corticomuscular (cEEG‐gEMG [gastrocnemius electromyography ...
Haifeng Zhao   +15 more
wiley   +1 more source

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